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Application of pyrazolopyrimidine derivative in treatment of hepatic fibrosis

A technology for pyrazolopyrimidine and liver fibrosis, applied in the field of pyrazolopyrimidine derivatives for the treatment of liver fibrosis, can solve problems such as no liver fibrosis use, and achieve the expansion of drug selectivity and the reduction of the degree of fibrosis , the effect of extending the scope of application

Inactive Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Description
  • Claims
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Problems solved by technology

[0004] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but there is no use in the treatment of liver fibrosis

Method used

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  • Application of pyrazolopyrimidine derivative in treatment of hepatic fibrosis
  • Application of pyrazolopyrimidine derivative in treatment of hepatic fibrosis
  • Application of pyrazolopyrimidine derivative in treatment of hepatic fibrosis

Examples

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Embodiment 1

[0025] Example 1 Study on Anti-immune Liver Fibrosis in Rats

[0026] 1. Experimental animals: male SD rats, clean grade, body weight (200±20) g, purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0027] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3. Pig serum, Beijing Yansheng Zhengbo Biotechnology Co., Ltd.; type III procollagen (PCIII), type IV collagen (CIV), hyaluronic acid (HA), laminin (LN) radioimmunoassay kits, Beijing North Biotechnology Research Pl...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of pyrazolopyrimidine derivatives in treatment of hepatic fibrosis. The liver fibrosis is related to liver tissue fibroblast. The pyrazolopyrimidine derivative disclosed by the invention can obviously reduce the fibrosis degree of tissues, including reduction of four levels of hepatic fibrosis, reduction oftissue fiber proliferation and the like, and has the good treatment effect on hepatic fibrosis.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating liver fibrosis. Background technique [0002] Hepatic fibrosis is the liver's self-healing response to various injuries, and is a common pathological process in the development of various chronic liver diseases to liver cirrhosis. Massive deposits in the interspaces. Hepatic fibrosis is common in most chronic liver diseases with different etiologies. If the etiology persists, liver fibrosis gradually aggravates, causing remodeling of liver lobules and blood vessels, and formation of pseudolobules and nodules, leading to liver cirrhosis, which seriously affects patients. health and life. Since liver fibrosis occurs in many chronic liver diseases, and fibrosis is an inevitable pathological process of severe fatal diseases such as liver cirrhosis and liver cancer, therefore, anti-hepatic fibrosis has become the top priority i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P1/16
CPCA61K31/519A61P1/16
Inventor 李柏霖覃秋琳韦杰吴水华巫鑫陈丹
Owner GUANGXI WUZHOU PHARMA GRP
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