Pharmaceutical composition for treating primary immune thrombocytopenia and preparation method thereof

A technology for thrombocytopenia and immunity, applied in the field of medicinal chemistry, can solve the problems of increased malignant tumors, opportunistic infections, and increased adverse reactions, and achieve the effects of fewer adverse reactions, reduced side effects, and low cost

Inactive Publication Date: 2020-02-28
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Clinical data show that the use of mycophenolate mofetil alone in the treatment of primary immune thrombocytopenia has certain limitations, opportunistic infections, increased chances of inducing malignant tumors, and increased adverse reactions

Method used

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  • Pharmaceutical composition for treating primary immune thrombocytopenia and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0023] This example discloses a pharmaceutical composition for treating primary immune thrombocytopenia, which comprises the following components in parts by weight: 50 parts of mycophenolate mofetil, 10 parts of Panax notoginseng, 30 parts of Radix Astragali, chicken 10 parts of Rhizoma vine, 20 parts of Poria cocos, 12 parts of Atractylodes macrocephala, 10 parts of donkey-hide gelatin, 20 parts of Codonopsis pilosula, 3 parts of roasted licorice, and 10 parts of madder.

[0024] This embodiment also discloses a preparation method of a pharmaceutical composition for treating primary immune thrombocytopenia, comprising the following steps:

[0025] Step 1: Weigh Panax notoginseng, Astragalus membranaceus, Caulis Spatholobus, Poria cocos, Atractylodes macrocephala, donkey-hide gelatin, Codonopsis pilosula, roasted licorice, and madder, chop them, add water to soak for 10 minutes, heat to boiling, let cool, separate and decoct the liquid, separate and decoct After the liquid is...

Embodiment 2

[0029] This example discloses a pharmaceutical composition for the treatment of primary immune thrombocytopenia, comprising the following components in parts by weight: 40 parts of mycophenolate mofetil, 10 parts of Panax notoginseng, 10 parts of astragalus, chicken 15 parts of Rhizoma Spathifolia, 15 parts of Poria cocos, 8 parts of Atractylodes macrocephala, 20 parts of donkey-hide gelatin, 20 parts of Codonopsis pilosula, 7 parts of roasted licorice, and 7 parts of madder.

[0030] This embodiment also discloses a preparation method of a pharmaceutical composition for treating primary immune thrombocytopenia, comprising the following steps:

[0031] Step 1: Weigh Panax notoginseng, Astragalus membranaceus, Caulis Spatholobus, Poria cocos, Atractylodes macrocephala, donkey-hide gelatin, Codonopsis pilosula, Zhigancao, madder, chop them, add water to soak for 20 minutes, heat to boil, let cool, separate the decocted liquid, separate and decoct After the liquid is released, th...

Embodiment 3

[0035] This example discloses a pharmaceutical composition for the treatment of primary immune thrombocytopenia, comprising the following components by weight: 30 parts of mycophenolate mofetil, 20 parts of Panax notoginseng, 20 parts of astragalus, chicken 20 parts of Spathiphyllum vine, 20 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 10 parts of donkey-hide gelatin, 10 parts of Codonopsis pilosula, 10 parts of roasted licorice, and 10 parts of madder.

[0036] This embodiment also discloses a preparation method of a pharmaceutical composition for treating primary immune thrombocytopenia, comprising the following steps:

[0037] Step 1: Weigh Panax notoginseng, Astragalus membranaceus, Caulis Spatholobus, Poria cocos, Atractylodes macrocephala, donkey-hide gelatin, Codonopsis pilosula, Zhigancao, madder, chop them, add water to soak for 30 minutes, heat to boiling, let cool, separate the decocted liquid, separate and decoct After the liquid is released, the me...

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Abstract

The invention relates to a pharmaceutical composition for treating primary immune thrombocytopenia and a preparation method thereof. The pharmaceutical composition is characterized by comprising, by weight, 1-80 parts of mycophenolate mofetil, 0.5-20 parts of pseudo-ginseng, 1-40 parts of radix astragali, 0.5-20 parts of caulis spatholobi, 0.5-20 parts of poria cocos, 0.5-20 parts of rhizoma atractylodis macrocephalae, 1-20 parts of colla corii asini, 1-20 parts of radix codonopsis, 1-10 parts of radix glycyrrhizae preparata and 1-10 parts of radix rubiae. The pharmaceutical composition has the advantages that by the joint effect of the mycophenolate mofetil and the traditional Chinese medicine materials, the primary immune thrombocytopenia can be treated, the total curative effect of themedicine is increased, and the pharmaceutical composition is few in untoward reaction, low in cost, capable of lowering the side effects of the mycophenolate mofetil on human bodies, small in toxic and side effects and evident in curative effect.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a pharmaceutical composition for treating primary immune thrombocytopenia and a preparation method thereof. Background technique [0002] Platelets are small pieces of cytoplasm that are dissociated from the cytoplasm of mature megakaryocytes in the bone marrow, and are extremely important for the body's hemostatic function. After trauma, platelets quickly adhere to the wound and aggregate into groups to form softer hemostatic plugs. Primary immune thrombocytopenia (ITP) is an immune syndrome and a common bleeding disorder. It is characterized by the existence of anti-platelet antibodies in the blood circulation, which causes excessive destruction of platelets. The general symptoms are subcutaneous and mucous membrane bleeding, such as skin ecchymosis, purpura, oral cavity and gum bleeding, etc. In severe cases, it can cause massive bleeding in the gastrointestinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P7/04A61K31/5377A61K35/36
CPCA61K31/5377A61K35/36A61K36/076A61K36/258A61K36/284A61K36/344A61K36/481A61K36/484A61K36/486A61K36/74A61K2236/331A61K2236/39A61P7/04A61K2300/00
Inventor 韩小霜郁晨燕李标有
Owner ZHUOHE PHARM GRP CO LTD
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