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Novel application of fructus tsaoko to preparation of antiviral medicines

A grass fruit and drug technology, applied in antiviral agents, pharmaceutical formulas, plant raw materials, etc., to achieve high safety, good curative effect, and wide application

Active Publication Date: 2020-02-28
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research report on the application of Caoguo in the treatment of anti-herpes simplex virus type 1

Method used

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  • Novel application of fructus tsaoko to preparation of antiviral medicines
  • Novel application of fructus tsaoko to preparation of antiviral medicines
  • Novel application of fructus tsaoko to preparation of antiviral medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1 Experimental materials

[0028] 1.1 Drugs

[0029] Invented medicine: grass fruit water extract, the traditional Chinese medicine grass fruit is extracted by water extraction method.

[0030] Positive drug: Acyclovir, batch number: 1411201, produced by Hubei Qianjiang Pharmaceutical Company.

[0031] 1.2 Virus strains

[0032] The F strain of herpes simplex virus type 1 (HSV-1) was purchased from the Institute of Virology, School of Medicine, Wuhan University, passed through Vero cells and frozen at -80°C for future use.

[0033] 1.3 cells

[0034] African green monkey kidney cells (Vero) were purchased from ATCC, USA, and stored in liquid nitrogen for future use.

[0035] 1.4 Main reagents

[0036] DMEM medium, batch number: SH30243.01, produced by HyClone Company; trypsin, batch number: J170024, produced by HyClone Company; cell proliferation-toxicity detection kit (CCK-8, batch number: BS350A, produced by biosharp Company, China); penicillin- Streptomycin ant...

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PUM

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Abstract

The invention provides application of a fructus tsaoko aqueous extract to preparation of antiviral medicines. In the novel application of fructus tsaoko to preparation of the antiviral medicines, according to action mechanism researches, the fructus tsaoko aqueous extract not only plays a role in an HSV-1 virus adsorption stage but also plays a role in a virus replication stage. Therefore, the fructus tsaoko aqueous extract integrates dual functions of prevention and treatment in anti-HSV-1 action and is excellent in curative effect, high in safety and extensive in application, thereby havinga compressive development and application prospect in application to new medicines for prevention and treatment of viral infection diseases such as HSV-1.

Description

technical field [0001] The present invention relates to the new application of Caoguo in the preparation of antiviral drugs. Background technique [0002] Viruses are the smallest of pathogenic microorganisms. They reproduce in cells. Their core is ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The outer shell is protein and does not have a cellular structure. Viruses are parasitic in host cells and rely on the host cell metabolic system for proliferation and replication. The virus replication process is as follows: ① virus recognition and adsorption to the surface of host cells; ② penetration into susceptible cells through the host cell membrane; ③ shedding; ④ synthesis of early regulatory proteins and nucleic acid polymerases; ⑤ viral genome (DNA or RNA) replication; ⑥ Structural protein in the later stage of synthesis; ⑦ Assembly of progeny virus; ⑧ Release of progeny virus from susceptible cells. The above process is a replication cycle. Antiviral drugs can ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P31/22A61K131/00
CPCA61K36/9064A61P31/22A61K2236/331
Inventor 代敏刘鳐蒲忠慧任科
Owner CHENGDU MEDICAL COLLEGE
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