A kind of fingerprint detection method of Wenjing Decoction
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A technology of fingerprint spectrum and detection method, which is applied in the detection field of medicinal preparations, can solve the problems of inability to reflect the overall characteristics of traditional Chinese medicine compound preparations, incomplete drug quality, etc., and achieve the effects of reducing artificial processing, good absorption value and stable baseline.
Active Publication Date: 2022-05-06
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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Existing literature only records the content determination of several components of Wenjing Decoction by HPLC method, but it is obviously not comprehensive to control the quality of its medicines simply by detecting the quantification of several index components, nor can it reflect the overall quality of Chinese medicine compound preparations. sexual characteristics
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Embodiment 1
[0096] 1. Preparation of Wenjingtang Standard Decoction Mixed Reference Substance Solution: Precisely weigh ferulic acid, paeoniflorin, cinnamon aldehyde, paeonol, gemaconone, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, liquiritin , ammonium glycyrrhizinate, and β-ecdysterone reference substance, add methanol to make mixed reference substances with mass concentrations of 129.5, 89.2, 321.4, 58.7, 232.6, 117.9, 235.6, 124.8, 136.2, 259.3, 285.6 μg / mL solution;
[0097] 2. Preparation of Wenjing Decoction Standard Decoction Test Solution: Weigh 1.67g each of Angelica, Chuanxiong, Paeoniae Alba, Cinnamon, Cortex Moutan, and Curcuma powder, 3.33g each of Ginseng, Licorice, and Achyranthes bidentata powder, add 300mL of water, mix Mix evenly, first heat to boiling with strong fire, then switch to slow fire and fry slowly. When the decoction reaches about 160mL, filter it while it is hot, add water to the filtrate to 250mL, accurately absorb 10mL of standard decoction of Wenji...
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Abstract
The present invention relates to a kind of fingerprint detection method of Wenjing Decoction, described method, the steps are as follows: 1) preparation of test solution: take by weighing 1-2g each of Angelica sinensis, Rhizoma Chuanxiong, Radix Paeoniae Alba, Cinnamon, Cortex Moutan, and Curcuma officinalis powder, Ginseng, licorice, and Achyranthes bidentata powder are 3-4g each, add 250-350mL of water, mix well, first heat to boiling with strong fire, then switch to slow fire and fry until the decoction reaches about 150-170mL, filter while hot, and the filtrate Add water to make up to 240‑260mL; accurately draw 8‑12mL of Wenjingtang standard decoction, add methanol to make up to 40‑60mL, airtight, weigh, ultrasonicate for 8‑12min, leave overnight, weigh again, use methanol Make up the lost quality, shake well, filter, and get the filtrate to get final product; 2) detection: take 5-15 μL of the test solution obtained in the previous step, inject it into a high-performance liquid chromatograph, and obtain a chromatogram; 3) result Judgment: The chromatogram obtained in the previous step is compared with the standard control fingerprint. If the similarity is greater than 90%, the sample is qualified.
Description
technical field [0001] The invention relates to a detection method of a medicinal preparation, in particular to a detection method of a traditional Chinese medicine Wenjing Decoction fingerprint. Background technique [0002] Irregular menstruation, dysmenorrhea, and metrorrhagia are common gynecological diseases, which not only bring great pain to patients, but also burden families and society. Wenjing Decoction is a classic prescription for regulating menstruation and relieving pain in traditional Chinese medicine. It comes from "Women's Encyclopedia of Good Prescriptions" written by Chen Ziming, a famous doctor in the Southern Song Dynasty. It is now included in the "Catalog of Ancient Classical Prescriptions". Composed of curcuma, ginseng, licorice, and achyranthes bidentata, it has the effects of warming the meridian and dispelling cold, promoting blood circulation and regulating menstruation. It is mainly used for late menstruation or too little, amenorrhea, and dysmen...
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