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Product for breast-cancer-II screening and evaluation based on saliva specific glycoprotein carbohydrate chain structure and application thereof

A breast cancer and glycoprotein technology, which can be used in measurement devices, instruments, scientific instruments, etc., can solve the problems of too many lectins, and the lack of simple and effective screening, diagnosis and evaluation of stage II breast cancer.

Pending Publication Date: 2020-04-10
深圳格道糖生物技术有限公司
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AI Technical Summary

Problems solved by technology

[0006] The above scheme requires more lectins when testing samples, and combined statistics are required, so the screening, diagnosis and evaluation of breast cancer stage II are still not simple and effective

Method used

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  • Product for breast-cancer-II screening and evaluation based on saliva specific glycoprotein carbohydrate chain structure and application thereof
  • Product for breast-cancer-II screening and evaluation based on saliva specific glycoprotein carbohydrate chain structure and application thereof
  • Product for breast-cancer-II screening and evaluation based on saliva specific glycoprotein carbohydrate chain structure and application thereof

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Experimental program
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Embodiment Construction

[0054] Previous studies have found that there are significant differences between breast cancer stage II salivary glycoprotein glycoforms and healthy volunteers, and the sugar chains recognized by PTL-II are significantly different between HV&BB&BC-I and BC-II groups ( figure 1 ). Based on this, we designed and completed the following experiments.

[0055] The relevant verification experiments and analysis of the present application are introduced in detail below, and the inventor's specific research and development process is not limited thereto.

[0056] 1. Research methods:

[0057] A lectin magnetic particle complex was prepared by coupling lectin PTL-II to the surface of iron ferric oxide nano-magnetic particles to enrich the specific glycoproteins in the mixed samples of saliva from each group, and the specific sugars were separated by PNGase F enzyme digestion method N-sugar chains on proteins, and mass spectrometric identification of sugar chains by Matrix-Assisted L...

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Abstract

The invention discloses a product for related breast-cancer-II screening and evaluation based on a saliva specific glycoprotein carbohydrate chain structure and application thereof. Whether a saliva sample subject is a breast-cancer-II (BC-II) patient or not can be judged by detecting whether a saliva sample contains any one or any combination of specific 22 N-carbohydrate chains or not. Correspondingly, the lectin playing a role in specific binding recognition is PTL-II and can be independently used as a reagent for recognizing a saliva specific glycoprotein carbohydrate chain structure to prepare related medical products.

Description

technical field [0001] The present invention relates to the determination of phase II markers of breast cancer based on saliva-specific glycoprotein and related products and applications. Background technique [0002] Breast cancer (Breast Cancer, BC) is the most common malignant tumor in women. Its main symptoms include breast lumps, nipple changes and discharge, and changes in skin contour. Early diagnosis of breast cancer mainly relies on mammography screening, and its definitive diagnosis requires biopsy and histopathology. However, the high cost and false positive rate of mammography screening limit its popularization and application in low-income countries, the acceptance rate of biopsy and histopathological examination is low, and the professional requirements of operators are high. [0003] In recent years, a large number of studies have shown that: with the occurrence and development of tumors, abnormal changes in glycosylation of glycoproteins are accompanied by ...

Claims

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Application Information

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IPC IPC(8): G01N30/08G01N30/72
CPCG01N30/08G01N30/72
Inventor 李铮阳佳君
Owner 深圳格道糖生物技术有限公司
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