2-cyano-3-thiophene substituted valeramide derivatives and their applications
A compound, methoxyl technology, applied in the field of pesticides, to achieve the effects of novel structure, good control effect and excellent activity
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Embodiment 1
[0059] compound preparation of
[0060] 0.01 mol of 4-methoxyacetophenone was dissolved in 10 mL of absolute ethanol, and 5 mL of 10% NaOH ethanol solution was added thereto. While stirring in an ice bath, slowly drop the mixture of 0.01mol thiophene-2-carbaldehyde and 10mL of absolute ethanol into the above mixed solution with a constant pressure dropping funnel, react at 0-5°C, and use a thin-layer silica gel plate to (TLC) to check the completion of the reaction. After the reaction is completed, add 5 mL of 10% NaOH ethanol solution to the reaction mixture, and slowly drop a mixed solution of 0.02 mol cyanoacetamide and 10 mL of absolute ethanol into the mixture with a constant pressure dropping funnel, and continue to cool at 0-5 ° C. The reaction was carried out, and TLC was used to check whether the reaction was complete. After the reaction was completed, a large amount of ice water was added to the solution, and the pH was adjusted to neutral with 10% hydrochloric a...
Embodiment 2
[0062] compound preparation of
[0063] 0.01 mol of 4-bromoacetophenone was dissolved in 10 mL of absolute ethanol, and 5 mL of 10% NaOH ethanol solution was added thereto. While stirring in an ice bath, slowly drop the mixture of 0.01mol thiophene-2-carbaldehyde and 10mL of absolute ethanol into the above mixed solution with a constant pressure dropping funnel, react at 0-5°C, and use a thin-layer silica gel plate to (TLC) to check the completion of the reaction. After the reaction is completed, add 5 mL of 10% NaOH ethanol solution to the reaction mixture, and slowly drop a mixed solution of 0.02 mol cyanoacetamide and 10 mL of absolute ethanol into the mixture with a constant pressure dropping funnel, and continue to cool at 0-5 ° C. The reaction was carried out, and TLC was used to check whether the reaction was complete. After the reaction was completed, a large amount of ice water was added to the solution, and the pH was adjusted to neutral with 10% hydrochloric aci...
Embodiment 3
[0066] compound preparation of
[0067] 0.01 mol of 4-methoxyacetophenone was dissolved in 10 mL of absolute ethanol, and 5 mL of 10% NaOH ethanol solution was added thereto. Under stirring in an ice bath, slowly drop a mixture of 0.01mol 5-bromothiophene-2-carbaldehyde and 10mL of absolute ethanol into the above mixed solution with a constant pressure dropping funnel, react at 0-5°C, and use a thin A silica gel plate (TLC) was used to check whether the reaction was complete. After the reaction is complete, add 5 mL of 10% NaOH ethanol solution to the reaction mixture, and slowly drip a mixed solution of 0.02 mol cyanoacetamide and 10 mL of absolute ethanol into the mixture with a constant pressure dropping funnel, and continue to The reaction was carried out at ℃, and the completion of the reaction was detected by TLC. After the reaction was completed, a large amount of ice water was added to the solution, and the pH was adjusted to neutral with 10% hydrochloric acid solu...
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