Biomarker for ossotide interventional therapy of osteoporosis, screening method and application

Abstract

The invention discloses a biomarker for an ossotide intervention therapy of osteoporosis. The biomarker comprises lipid and lipoid molecules, organic acid and derivatives thereof and / or neurotransmitter substances, wherein the lipid and lipoid molecules are any one or more selected from taurine, arachidonic acid, 1-palmitoyl-2-hydroxy-sn-3-phosphoethanolamine, (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)-4, 7, 10, 13, 16, 19-docosahexaenoic acid, 1-stearoyl-2-hydroxy-sn-3-glycerol-3-phosphorylcholine, taurine deoxycholic acid, taurodeoxycholic acid and taurocholic acid. The invention discloses a screening method of the biomarker as well as an application of the biomarker. Exemplary research is provided for evaluation of active functions of natural products, and theoretical support is provided for systematic evaluation of anti-osteoporosis activity of ossotide and development of ossotide products with bioactive functions.

Description

technical field [0001] The invention belongs to the field of nutrition and functional food, relates to a biomarker in osteoporosis intervention therapy, also relates to a screening method for biomarkers of osteoporosis anti-osteoporosis activity, and also relates to an osteopeptide intervention treatment of osteoporosis The use of biomarkers in . Background technique [0002] As my country enters an aging society, the incidence of osteoporosis among residents is also increasing year by year. At present, there are about 93 million osteoporosis patients in my country, and it is predicted that the number of osteoporosis patients will be close to 200 million by 2050. Osteoporosis is a systemic bone metabolic disease characterized by osteopenia, degeneration of bone microstructure, and increased bone fragility. Osteoporosis-induced fractures have increased the morbidity and mortality, and have become a serious public health problem. Clinically, drugs for the treatment of osteo...

AI Technical Summary

Problems solved by technology

At present, a certain degree of research has been carried out on the anti-osteoporosis activity and mechanism of osteopeptide, but only by observing one or a few typical indicators in bone tissue or organs to evaluate its anti-osteoporosis activity. There are great limitations and one-sidedness at the level, and the mechanism of action of osteopeptide cannot be systematically and comprehensively reflected and explained, which greatly limits its development and utilization.

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