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Non-surgical intervened fish artificial lung system and application thereof

An artificial lung and fish technology, applied in the field of biology, can solve the problems of few applications and the inability of zebrafish to be widely used in the research of respiratory diseases, and achieve the effect of ensuring stability

Active Publication Date: 2020-05-05
TIANJIN CHEST HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Because fish use gills for gas exchange and do not have a respiratory system like humans, there are few applications in the field of respiratory disease research. As a result, zebrafish have not been widely used in the research of respiratory diseases.

Method used

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  • Non-surgical intervened fish artificial lung system and application thereof
  • Non-surgical intervened fish artificial lung system and application thereof
  • Non-surgical intervened fish artificial lung system and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1, such as Figure 7 Shown in, the present invention is the artificial lung system of a kind of non-surgical intervention fish, comprises adjustable culture fluid O 2 Partial pressure, CO 2 Partial pressure, H + Concentration, HCO 3 - A membrane exchange system with any one or several parameters of concentration.

Embodiment 2

[0043] Embodiment 2, a non-surgical artificial lung system for fish, including a control system 1, a membrane exchange system 3, a rearing tank 4 and a variety of air sources; the membrane exchange system 3 includes an exchange chamber 309 and an exchange membrane 310 The exchange membrane 310 is placed in the exchange chamber 309 of premixed water; the multiple gas sources are communicated with the air inlet of the exchange membrane 310; the inside of the exchange membrane 310 is an air cavity, and the outside of the membrane is premixed water; The feeding liquid in the exchange chamber 309 is connected to the water inlets 402 of multiple feeding tanks through pipes; the various air sources are provided with various sensors and control valves; the control system 1 is electrically connected to the various sensors and control valves respectively.

[0044] The sensors include one or more combinations of pressure sensors, flow sensors, gas partial pressure sensors, pH sensors, tem...

Embodiment 3

[0046] Example 3, such as figure 1 and Figure 4 As shown in , the water inlet of the exchange chamber 309 is respectively connected to the acidic liquid source 9, the alkaline liquid source 10 and the clean water source 11 through pipelines; There are various sensors and control valves; the control system 1 is electrically connected to various sensors and control valves on each unit respectively.

[0047] The membrane exchange system 3 includes a circulating pump 301, a membrane exchange system sensor 302, an exchange membrane inlet 303, an exchange chamber housing 304, a clean water inlet 305, an acidic liquid source inlet 306, an alkaline liquid source inlet 307, and an exchange membrane outlet. Air port 308 , exchange chamber 309 , exchange membrane 310 and air cavity 311 .

[0048] The acidic liquid source 9 enters the exchange chamber 309 through the acidic liquid source inlet 306; the alkaline liquid source 10 enters the exchange chamber 309 through the alkaline liqui...

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Abstract

The invention discloses a non-surgical intervened fish artificial lung system. The non-surgical intervened fish artificial lung system comprises a film exchange system which can adjust parameters of any one or several including O2 partial pressure, CO2 partial pressure, H<+> concentration and HCO3<-> of breeding liquid, can be used for establishing an animal model simulating a human respiratory system, and can be applied to research of human respiration diseases of hyoxemia, hyperoxemia, hypocapnia, hypercarbia and the like.

Description

technical field [0001] The invention relates to the technical field of biology, in particular to a non-surgical artificial lung system for fish and its application in establishing a model for simulating human respiratory diseases. Background technique [0002] With the development of population aging, the intensification of environmental pollution, the spread of tobacco, the abuse of drugs and poisons, the raging of respiratory infectious diseases, etc., the incidence of respiratory abnormalities caused by respiratory diseases and other related system diseases is increasing year by year The cumulative number of patients is also increasing rapidly, and the proportion and number of patients with chronic respiratory diseases are increasing rapidly. The mortality rate of chronic respiratory diseases has ranked third in the world's cause of death, and the medical burden and social economic burden are becoming more and more serious. For example: hypoxemia, hyperoxemia, hypocapnia,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K61/10A01K63/00A01K63/04G01D21/02
CPCA01K61/10A01K63/003A01K63/045A01K63/042G01D21/02Y02A40/81
Inventor 赵晓赟彭茜王子琦王慧泉陈冬艳魏翼彤张国新冯雪
Owner TIANJIN CHEST HOSPITAL
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