Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment

An antibacterial and antifungal agent, long-acting technology, applied in the field of antibacterial and antifungal agents, can solve problems such as lack of versatility, hidden dangers to the health of astronauts, easy discoloration, etc., to achieve drug resistance, no hidden danger of discoloration, and no toxic components Effect

Active Publication Date: 2020-05-08
SHENZHOUSPACEBIOTECHGRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions have a limited antibacterial time and are easy to change color after being used on textiles. They are not universal in the antibacterial application of various materials in the space station.
And more importantly, the accumulation toxicity of silver nano-ions in the human body has received more and more attention. Therefore, the large-scale use of silver-ion anti

Method used

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  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment
  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment
  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] The present invention provides a preparation method of the long-acting antibacterial and antifungal agent according to the above scheme, which includes the following steps:

[0028] The organic silicon quaternary ammonium salt, stabilizer, synergist, film-forming agent and water are mixed to obtain a long-acting antibacterial and antifungal agent.

[0029] In the specific embodiment of the present invention, it is preferable to use a commercially available silicone quaternary ammonium salt solution as a raw material to prepare the antibacterial and antifungal agent of the present invention. When a commercially available silicone quaternary ammonium salt solution is used as a raw material, propylene glycol is preferably selected as the raw material. The organic silicon quaternary ammonium salt solution of the solvent, the mass concentration of the organic silicon quaternary ammonium salt solution is preferably 10-60%, more preferably 50%, when the commercially available organi...

Example Embodiment

[0034] Example 1

[0035] The organic silicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (trimethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride, the mass concentration is 50%) is used as the raw material to prepare Example 1 Antibacterial and antifungal agent, mix organosilicon quaternary ammonium salt solution, chitosan, dopamine hydrochloride, poloxamer and water, stir for 10 minutes, adjust the pH to 8.5 with 0.1% sodium hydroxide solution, and fill.

[0036] In the obtained product, each 100g product contains: 0.5g of silicone quaternary ammonium salt, 0.5g of propylene glycol, 1.0g of chitosan, 0.2g of dopamine hydrochloride, 4071.2g of poloxamer, and the balance of water.

[0037] Stability test: The test temperature is 25℃, and the drug stability test box is placed. The result shows that the product can be stored stably at room temperature for more than 2 years.

[0038] Textile surface anti-mold test, using the most common fungus...

Example Embodiment

[0045] Example 2

[0046] Using organosilicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (triethoxysilyl) propyl-N-octadecyl dimethyl ammonium chloride, the mass concentration is 60%) as the raw material Preparation Example 2 Antibacterial and antifungal agent, mix organosilicon quaternary ammonium salt solution, pentanediol, chitosan, dopamine hydrochloride, polyvinylpyrrolidone K30 and water, stir for 10 minutes, and fill.

[0047] In the obtained product, each 100g product contains: 0.2g of organosilicon quaternary ammonium salt, 0.13g of propylene glycol, 0.8g of pentanediol, 1.0g of chitosan, 0.1g of dopamine hydrochloride, 300.5g of polyvinylpyrrolidone K, and the balance of water.

[0048] The stability test was carried out according to the method of Example 1, and the results showed that the product can be stably stored at room temperature for more than 1 year.

[0049] Anti-mold test on aluminum alloy surface, using the most common fungu...

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Abstract

The invention relates to the technical field of antibacterial mildew inhibitors, and provides a long-acting antibacterial mildew inhibitor, a preparation method thereof, and an application of the long-acting antibacterial mildew inhibitor in a space station environment. The long-acting antibacterial mildew inhibitor takes an organosilicon quaternary ammonium salt as a main sterilization component,can inhibit bacteria, saccharomycetes and fungi for a long time, is high in safety, and has no acute toxicity or accumulated toxicity hidden danger; the antibacterial mildew inhibitor has long-actingantibacterial and mildew-proof performance, and bacteria and mildew do not easily generate drug resistance; no color change hidden danger or toxic component exists, and long-term storage can be achieved; and furthermore, propylene glycol and the like are used as stabilizers, so the VOC release amount can be reduced, and the situation that toxic gas such as methyl alcohol volatilizes in the special environment of the space station and affects the health of astronauts is avoided. The long-acting antibacterial mildew inhibitor can meet the long-acting antibacterial and mildew-proof requirementsof aluminum alloy and textiles in a space station cabin, the VOC release amount of the product is low, and the air quality requirement of the space station is met.

Description

technical field [0001] The invention relates to the technical field of antibacterial and antifungal agents, in particular to a long-acting antibacterial and antifungal agent, a preparation method thereof and an application in a space station environment. Background technique [0002] Microorganisms on the space station will affect the health of astronauts and the safety of the cabin environment. Studies have shown that the growth rate of microorganisms on the space station is significantly faster than that of the ground control group. Researchers found 84 kinds of microorganisms in the cabin of the International Space Station, and identified 18 types of bacteria and 12 types of fungi, including 49 types of bacteria and 35 types of fungi. Microorganisms exist in the air, water and surfaces of the Mir space station. In the International Space Station, the fungi attached to the surface of materials are mainly Penicillium, Aspergillus and Cladosporium, all of which have a tend...

Claims

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Application Information

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IPC IPC(8): A01N55/10A01N33/10A01N37/44A01N43/16A01P1/00A01P3/00
CPCA01N33/10A01N37/44A01N43/16A01N55/00
Inventor 王小雪李飞李明刘庆华郭飞马王凯马峰
Owner SHENZHOUSPACEBIOTECHGRP
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