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Application of angiopoietin-like protein 7 in prognosis evaluation of heart failure

An angiopoietin and heart failure technology, applied in the field of heart disease detection, to achieve the effect of accurate results, good application progress and value

Active Publication Date: 2020-05-08
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is a lack of a marker that can accurately represent the development stage of heart failure and guide the treatment and prognosis of the disease to a certain extent

Method used

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  • Application of angiopoietin-like protein 7 in prognosis evaluation of heart failure
  • Application of angiopoietin-like protein 7 in prognosis evaluation of heart failure

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Effect test

Embodiment 1

[0021] 1. Experimental method

[0022] (1) Patient enrollment

[0023] This study selected patients with heart failure who were hospitalized in the Department of Cardiovascular Medicine of the First Affiliated Hospital of Sun Yat-sen University from August 2015 to February 2017. Each patient was diagnosed with acute exacerbation of chronic heart failure or acute heart failure by 2 attending physicians or above cardiovascular specialists on the day of admission (diagnosis in accordance with the "2014 Chinese Guidelines for the Diagnosis and Treatment of Heart Failure"), and further evaluation Whether it meets the inclusion criteria and exclusion criteria, and patients who do not meet the requirements or have incomplete clinical data are excluded according to the exclusion criteria. All test subjects have been informed in detail of their research purpose, research content, research methods, and follow-up methods, and patients and their families will be deemed to be formally enr...

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Abstract

The invention discloses an application of angiopoietin-like protein 7 in prognosis evaluation of heart failure. When a serum sample of a heart failure patient is detected by using an enzyme-linked immunosorbent assay method, and the content of the angiopoietin-like protein 7 in the sample is greater than or equal to 869 pg / mL, the patient has a high probability of poor prognosis, i.e., events of 30-day death and 90-day death can occur at a large probability. According to the application, the angiopoietin-like protein 7 is used as a marker for prognosis evaluation of heart failure, and the prognosis condition of the heart failure patient can be judged by detecting the concentration of the ANGPTL7 in serum. Through predicting the prognosis condition of the heart failure patient by utilizingthe marker, the application is simple and easy to implement and precise in result, has a guiding effect on a clinical treatment scheme, has good application advancement and value, and is worthy of vigorous popularization and protection.

Description

technical field [0001] The present invention relates to the technical field of heart disease detection, and more specifically, relates to the application of angiopoietin-like protein 7 in the evaluation of heart failure prognosis. Background technique [0002] Cardiovascular disease is currently the disease with the highest mortality rate in the world, which seriously threatens human life and health. Studies have shown that the number of deaths from cardiovascular diseases is increasing substantially every year. Cardiovascular disease has a high incidence rate and a high mortality rate, and with the aging of the population, the deterioration of the living environment, and the unhealthy lifestyle, the harm it brings is becoming more and more significant. The common endpoint of various cardiovascular diseases such as: hypertension, myocardial infarction, ischemic cardiomyopathy, myocarditis, dilated cardiomyopathy, hypertrophic cardiomyopathy, etc. is heart failure. Heart fa...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/515G01N2800/325G01N2800/52
Inventor 刘晨董吁钢赵静静何昕张冲宇
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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