Small interfering nucleic acid for inhibiting novel coronavirus, and composition and applications thereof

A new type of nucleotide technology, applied in the field of biomedicine, can solve the problem of lack of effective antiviral drugs for SARS-CoV-2 virus
CN111139241AActive Publication Date: 2020-05-12SUZHOU GENEPHARMA +1
1 Cites 21 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUZHOU GENEPHARMA
Publication Date
2020-05-12

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses small interfering nucleic acid for inhibiting novel coronavirus, and a composition and applications thereof. The siRNA contains a positive-sense strand and a antisense strand;the siRNA is 21-si-SP-2069, 21-si-SP-2289, 21-si-SP-3292, 21-si-P3-242, 21-si-P8-62, 21-si-P8-164, 21-si-P10B-158, 21-si-P14-19, 21-si-NP-722, 21-si-NP-1123, 21-si-NS-2139 or 21-si-NS-2798; and partial nucleotide of the positive-sense strand or the antisense strand is 2'-O-methyl ribonucleotide, and partial phosphate groups are phosphorothioate groups. The provided brand-new siRNA and the composition thereof can effectively prevent and / or treat novel coronavirus.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of biomedical technology, in particular to a small interfering nucleic acid that inhibits gene expression of a novel coronavirus and the application of the small interfering nucleic acid in the preparation of a pharmaceutical composition for preventing and / or treating novel coronavirus pneumonia. Background technique

[0002] In late 2019 and early 2020, a new type of coronavirus pneumonia (CoronaVirusDisease2019, COVID-19) broke out in Wuhan, China. COVID-19 is an acute infectious pneumonia, and researchers have found that its pathogen is caused by a novel betacoronavirus not previously found in humans, which was subsequently named SARS-CoV by the World Health Organization (WHO)- 2. The initial symptoms of COVID-19 patients are mostly fever, fatigue and dry cough, and gradually develop severe symptoms such as dyspnea. The prognosis of most patients is good, and acute respiratory distress syndrome, septic sh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More