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Application of FDPS (farnesyl pyrophosphate synthase) for preparing medicine capable of treating nonalcoholic steatohepatitis

A steatohepatitis and non-alcoholic technology, which is applied in the direction of drug combination, microbial measurement/testing, and pharmaceutical formulations, can solve the problems of lack of in-depth research in application, and achieve the effect of reducing liver lipid deposition

Pending Publication Date: 2020-05-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of targeted inhibition of FDPS in diseases such as non-alcoholic fatty liver disease has not been studied in depth

Method used

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  • Application of FDPS (farnesyl pyrophosphate synthase) for preparing medicine capable of treating nonalcoholic steatohepatitis
  • Application of FDPS (farnesyl pyrophosphate synthase) for preparing medicine capable of treating nonalcoholic steatohepatitis
  • Application of FDPS (farnesyl pyrophosphate synthase) for preparing medicine capable of treating nonalcoholic steatohepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] FDPS is a potential target for the treatment of NASH

[0036] 1. Construction of NASH model:

[0037] Model 1: 5-week-old male C57BL / 6J mice (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were raised in a standard SPF environment (no special pathogens, constant temperature at 25°C, and lighting at intervals of 12 hours). The mice were divided into two groups, a group of mice (n=6) were fed with maintenance feed (NC), and a group of mice (n=6) were fed with high-fat diet (HFD) (the high-fat feed was purchased from the American Research Diet company, Cat. No. D12492). After 21 weeks, the mice were anesthetized with chloral hydrate. The mice were dissected, and the plasma was collected. One lobe of the liver was quick-frozen in liquid nitrogen, stored at ultra-low temperature, and one lobe of the liver was fixed in formalin.

[0038] Model 2: 5-week-old male C57BL / 6J mice (purchased from Beijing Weitong Lihua Experimental Animal Technolog...

Embodiment 2

[0103] The therapeutic effect of alendronate sodium on NASH

[0104] Construction of HFFD model: 5-week-old male C57BL / 6J mice (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were bred in a standard SPF environment (constant temperature 25°C, lighting intervals of 12 hours). During modeling, they were fed with high-fat feed and water containing fructose (2.31g fructose / 100mL drinking water) (HFFD), free to eat and drink.

[0105] Alendronate sodium administration regimen: divided into groups after feeding for 10 weeks, solvent control group (Control / Ctrl) (n=8) and alendronate sodium administration group (ALN) (purchased from Apexbio, USA, product number B6586) (n=9). On every Monday, Wednesday, and sixth day, the mice in the control group and the alendronate sodium administration group were injected intraperitoneally with equal volumes of normal saline and alendronate sodium solution (1 mg / kg, alendronate sodium solid powder for physiological ...

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PUM

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Abstract

The invention utilizes a high-fat high-sugar diet induced nonalcoholic steatohepatitis (short for NASH) mouse, discloses that farnesyl pyrophosphate synthase (FDPS) can be used as a potential therapeutic target for the NASH, proves a treatment function of the antagonist, i.e., alendronate sodium, of the FDPS for the NASH, and provides a new thought for developing NASH treatment medicines.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of FDPS in the preparation of medicines for preventing and / or treating non-alcoholic steatohepatitis. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) has become one of the most serious public health problems, with a global incidence of about 25%. With the development of my country's economy and changes in eating habits, the incidence of non-alcoholic fatty liver disease has increased year by year, showing a trend of younger age, and has become one of the most important chronic liver diseases in my country. [0003] Nonalcoholic steatohepatitis (NASH) is the core link of NAFLD, which is developed on the basis of nonalcoholic steatosis of the liver (NAFL). For liver fibrosis, cirrhosis, and even liver cancer. In addition, it is also involved in the development of other chronic diseases such as diabetes and atherosclerosis. [0004] At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883A61K31/663A61K31/675A61K49/00A61P1/16A61P3/06
CPCC12Q1/6883A61K31/663A61K31/675A61K49/0008A61P1/16A61P3/06C12Q2600/136
Inventor 王丽蕊钱民怡张羽飞
Owner CHINA PHARM UNIV
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