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Helicobacter pylori egg yolk antibody freeze-dried powder, preparation method and application preparation

A technology of Helicobacter pylori and egg yolk antibody, applied in the direction of antibody, freeze-drying delivery, chemical instruments and methods, etc., can solve the problems of not recommending treatment, increasing drug resistance, etc., achieving no toxic side effects, good effect, manufacturing and use handy effect

Inactive Publication Date: 2020-05-29
珠海华敏医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to increasing drug resistance, HP eradication rates have dropped from an initial 97% to less than 70% at present, even with increased doses and duration of treatment
[0004] In addition to the decline in the eradication rate, the current chemotherapeutics still has certain limitations: for special populations such as those who have failed repeated chemotherapies, children who must receive treatment, those with liver and kidney dysfunction, and lactating women, etc., currently Chemotherapy must be used with extreme caution, or treatment is not recommended
[0007] However, there is no Helicobacter pylori egg yolk antibody freeze-dried powder prepared by Helicobacter pylori egg yolk antibody and its application preparation at present

Method used

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  • Helicobacter pylori egg yolk antibody freeze-dried powder, preparation method and application preparation
  • Helicobacter pylori egg yolk antibody freeze-dried powder, preparation method and application preparation
  • Helicobacter pylori egg yolk antibody freeze-dried powder, preparation method and application preparation

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Embodiment Construction

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] Such as figure 1 Shown, the preparation method of Helicobacter pylori egg yolk antibody freeze-dried powder comprises the following steps:

[0023] S1. Antigen preparation: Take Helicobacter pylori No. 11637, pass passage on solid TYCSB agar slant respectively, culture it under anaerobic conditions at 37°C for 48 hours, and obtain the pure species of Helicobacter pylori through PCR identification, in liquid TYCSB medium The bacterial cells were collect...

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Abstract

The invention discloses helicobacter pylori egg yolk antibody freeze-dried powder, a preparation method and an application preparation. The preparation method comprises the following steps of S1, preparing an antigen; S2, selecting an adjuvant, immunizing a laying hen and taking eggs; S3, extracting an egg yolk antibody and preparing the helicobacter pylori egg yolk antibody freeze-dried powder; and S4, performing packaging, inspecting and dispatching. Helicobacter pylori egg yolk antibody freeze-dried powder capsules and cosolvents are good in effect, convenientin manufacturing and use and free of toxic or side effect; the preparation adopting the helicobacter pylori egg yolk antibody freeze-dried powder can be used for directly identifying a helicobacter pylori surface antigen and has targeted inhibition and killing effects on complete and active helicobacter pylori.

Description

technical field [0001] The invention relates to a freeze-dried powder of helicobacter pylori egg yolk antibody, a preparation method and an application preparation. Background technique [0002] The infection rate of Helicobacter pylori in my country exceeds 50%, and the number of people is as high as more than 800 million, and no less than 90 million people need treatment every year. Helicobacter pylori infection is the main cause of gastritis, gastric ulcer, duodenal ulcer and gastric cancer. Helicobacter pylori has been identified as a class I carcinogen by the World Health Organization, and more than 95% of patients who died from gastric cancer were infected with Helicobacter pylori. my country is a country with a high incidence of gastric cancer, and half of the world's new gastric cancer patients and deaths due to gastric cancer each year are from China. Prevention and treatment of Helicobacter pylori infection is the key to reduce the incidence of gastric cancer. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/12C07K16/02A61K9/19A61K39/40A61P31/04
CPCC07K16/121C07K16/02A61K9/19A61P31/04C07K2317/73C07K2317/76A61K2039/505
Inventor 安敏王宇章真王文
Owner 珠海华敏医药科技有限公司