Pyrazinamide compound and application thereof
A kind of technology of pyrazinamide and compound, applied in the field of fungicides, can solve the problems such as structural pyrazinamide compounds that have not been reported
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Embodiment 1
[0087] The preparation of embodiment 1 compound 270:
[0088]
[0089] Add 3-methylpyrazine-2-carboxylic acid (200 mg, 1.04 mmol), 10 milliliters of toluene and 1 milliliter of thionyl chloride into the reaction flask, and react at reflux for 2 hours, spin off excess thionyl chloride and solvent for later use . 2-Methyl-3-(pentyl-2-oxy)aniline (201 mg, 1.04 mmol) was dissolved in 10 mL of dichloromethane, and 1 mL of triethylamine was added. The prepared acid chloride was dissolved in dichloromethane, added dropwise to the above mixture, and reacted at room temperature for 2 hours. The reaction solution was poured into 30 ml of water, extracted three times with dichloromethane, and the organic layer was taken. The organic layer was washed successively with saturated aqueous sodium bicarbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (eluent...
Embodiment 2
[0090] Preparation of Example 2 Compound 344:
[0091]
[0092] Add 3-methylpyrazine-2-carboxylic acid (200 mg, 1.04 mmol), 10 milliliters of toluene and 1 milliliter of thionyl chloride into the reaction flask, and react at reflux for 2 hours, spin off excess thionyl chloride and solvent for later use . 2-Methyl-3-(hexyl-2-oxy)aniline (216 mg, 1.04 mmol) was dissolved in 10 mL of dichloromethane, and 1 mL of triethylamine was added. The prepared acid chloride was dissolved in dichloromethane, added dropwise to the above mixture, and reacted at room temperature for 2 hours. The reaction solution was poured into 30 ml of water, extracted three times with dichloromethane, and the organic layer was taken. The organic layer was washed successively with saturated aqueous sodium bicarbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (eluent: ethyl ...
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