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Meldonium as the application and medicine for preventing or treating acute brain injury at high altitude

A technology for acute brain injury and meldonium, applied in the field of biomedicine, can solve the problem of single category

Active Publication Date: 2021-06-11
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently, acetazolamide is the drug that has been marketed internationally to prevent altitude sickness, and Rhodiola is a drug that has been marketed in China, and the category is relatively single.

Method used

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  • Meldonium as the application and medicine for preventing or treating acute brain injury at high altitude
  • Meldonium as the application and medicine for preventing or treating acute brain injury at high altitude
  • Meldonium as the application and medicine for preventing or treating acute brain injury at high altitude

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Meldonium was administered at a dose of 50 mg / kg.

[0109] The solid oral medicament of the present invention is composed of the following materials: 200 parts of meldonium, 10 parts of diluent, 10 parts of lubricant, 10 parts of binder, 10 parts of disintegrant, 10 parts of boiling mixture, 10 parts of sweetener, 2 parts of dye, 10 parts of wetting agent, 5000 parts of distilled water;

[0110] The above-mentioned solid oral medicine was administered continuously for three days, and the dosage was 8 mL / kg.

Embodiment 2

[0112] Meldonium was administered at a dose of 100 mg / kg.

[0113] The solid oral medicament of the present invention is composed of the following materials: 200 parts of meldonium, 10 parts of diluent, 10 parts of lubricant, 10 parts of binder, 10 parts of disintegrant, 10 parts of boiling mixture, 10 parts of sweetener, 2 parts of dye, 10 parts of wetting agent, 5000 parts of distilled water;

[0114] The above-mentioned solid oral medicine was administered continuously for three days, and the dosage was 8 mL / kg.

Embodiment 3

[0116] Meldonium was administered at a dose of 100 mg / kg.

[0117] The solid oral medicament of the present invention is composed of the following materials: 200 parts of meldonium, 10 parts of diluent, 10 parts of lubricant, 10 parts of binder, 10 parts of disintegrant, 10 parts of boiling mixture, 10 parts of sweetener, 2 parts of dye, 10 parts of wetting agent, 5000 parts of distilled water;

[0118] The above-mentioned solid oral medicine was administered continuously for three days, and the dosage was 8 mL / kg.

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Abstract

The meldonium of the present invention is used as the prevention or treatment of plateau acute brain injury, and the meldonium is applied to the prevention or treatment of plateau acute brain injury. According to the research of the present invention, it is found that meldonium can effectively reduce or improve the brain injury caused by high altitude hypoxic environment. Therefore, the present invention relates to the use of meldonium for preventing acute brain injury at high altitude. The test shows that Meldonium has a significant protective effect on the damage of brain nerve cells caused by hypobaric hypoxia, and the effect is equivalent to that of the positive control drug acetazolamide. Meldonium can significantly reduce pathological damages such as nerve cell shrinkage, nuclear pyknosis and nuclear fragmentation caused by plateau hypoxia, and can effectively improve brain blood supply deficiency caused by plateau hypoxia; in addition, meldonium can significantly improve Mitochondrial dysfunction in the hippocampus induced by plateau hypoxia reduces oxidative stress damage in brain tissue.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the medicinal use of meldonium for preventing or treating acute brain injury at high altitude. Background technique [0002] Altitude sickness, also known as altitude sickness (mountain sickness), is an idiosyncratic and common disease in plateau areas above 3000m above sea level. The collective name of the clinical syndromes is the special state of organs, tissues, cells, etc. to adapt to the hypoxic environment. [0003] The acute high-altitude brain damage involved in the present invention includes, but is not limited to, high-altitude headache, high-altitude coma, high-altitude cerebral edema, and diseases in which brain abnormalities exist simultaneously or alone. [0004] The clinical manifestations of high-altitude brain damage described in the present invention are selected from headache, dizziness, rapid heart rate, chest tightness, shortness of breath, deep breat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/205A61K9/72A61K9/12A61P25/00A61P9/10
CPCA61K9/0019A61K9/0053A61K9/0073A61K31/205A61P9/10A61P25/00
Inventor 王永安骆媛刘凤英何欢欢高翔隋昕杨军孙阳阳
Owner ACADEMY OF MILITARY MEDICAL SCI
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