New application of sodium sulfite

A sodium sulfite, disease technology, applied in the new application field of sodium sulfite, can solve problems such as useless pharmaceutical fields

Inactive Publication Date: 2014-04-30
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Sodium sulfite has long been used as a chemical reagent and as a food additive, but not in pharmaceuticals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, sodium sulfite (Na 2 SO 3 ) Protective effect on high altitude hypoxic injury mice

[0026] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely. In this experiment, the mice were randomly divided into groups.

[0027] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0028] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, and 25 mg / Kg body weight and given intraperitoneal injection for 3 consecutive days, and injected once a day. The acute plateau hypoxia experiment was started 4 hours after the last injection. The control group was the blank control group and physiological...

Embodiment 2

[0035] Embodiment 2, sodium sulfite (Na 2 SO 3 ) Protective effect on mice injured by hypoxia (mine operation) under atmospheric pressure

[0036] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely. In this experiment, the mice were randomly divided into groups.

[0037] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0038] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, 25mg / Kg body weight and given intraperitoneal injection, Na 2 SO 3 The intraperitoneal injection was performed once a day for 3 consecutive days, and the acute normal-pressure hypoxia experiment was started 4 hours after...

Embodiment 3

[0045] Embodiment 3: sodium sulfite (Na 2 SO 3 ) Protective effect on ischemic hypoxic injury mice

[0046] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely. In this experiment, the mice were randomly divided into groups.

[0047] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0048] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, and 25 mg / Kg body weight and given intraperitoneal injection for 3 consecutive days, and injected once a day. The ischemic hypoxic injury experiment was started 4 hours after the last injection. The middle cerebral artery infarction (MCAO) model was prepared b...

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PUM

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Abstract

The invention discloses new application of sodium sulfite (Na2SO3), namely the application in the preparation of medicines and functional beverages for preventing diseases related to hypoxia-induced injury and / or ischemia-hypoxia. By the medicines or the functional beverages for preventing the diseases related to the hypoxia-induced injury and / or the ischemia-hypoxia prepared by taking the Na2SO3 as an active ingredient, an organism is in a hypoxia (such as high altitude hypoxia and mine hypoxia) pre-conditioning state, so that the aims of preventing the diseases (such as high altitude pulmonary edema, high altitude cerebral edema, cerebral ischemia, cardiac ischemia and respiratory distress) related to the hypoxia-induced injury and / or the ischemia-hypoxia are achieved. The medicines disclosed by the invention have the following advantages: 1) obvious treatment effect; 2) no toxic or side effects, and high safety; 3) low cost of Na2SO3; 4) convenience for medication (convenience for carrying and taking).

Description

[0001] The present invention is a divisional application of the patent application with the filing date of November 8, 2011, the application number of 201110349992.5, and the title of the invention being "New Uses of Sodium Sulfite". technical field [0002] The present invention belongs to the new application of compounds, in particular to the application of sodium sulfite in the preparation of medicines and / or health care products for preventing hypoxic injury and / or ischemic hypoxic related diseases. Background technique [0003] Oxygen is the basis of life activities of living organisms. Relatively closed spaces such as plateaus and mines, as well as factors such as vascular blockage and blood circulation disorders can cause hypoxia to varying degrees. Hypoxia can not only change the physiological functions of living organisms, but also cause a series of injuries and diseases in severe cases. For example, cerebral ischemia and hypoxia can cause stroke and nervous system d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A23L1/29A23L2/38A61P39/00A61P7/10A61P9/10A61P11/00A23L33/00A23L33/15
Inventor 张成岗李伟光何国维高艳蒋斌李志慧吴永红
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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