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Temporary orthopaedic implant and preparation method thereof

An implant and orthopedic technology, applied in the field of biomedical materials, can solve the problems of low mechanical properties of chitosan/GP hydrogel, poor biodegradability of polymethyl methacrylate, and fast degradation rate, etc., to improve mechanical properties , improve the mechanical strength, the effect of not easy to agglomerate

Inactive Publication Date: 2020-06-19
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the application of chitosan / GP hydrogels is limited due to their lower mechanical properties and faster degradation rate in vivo.
[0004] The Chinese invention patent with application number 201510252453.8 discloses an injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and its preparation method, using polymethyl methacrylate as a mechanical support Scaffolds, chitosan-based thermosensitive adhesives are used as pore-forming agents, bone-conducting materials and drug carriers to form injectable porous three-dimensional bone cement composites with good biocompatibility and mechanical properties, but polymethacrylic acid Methyl esters are poorly biodegradable

Method used

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  • Temporary orthopaedic implant and preparation method thereof
  • Temporary orthopaedic implant and preparation method thereof
  • Temporary orthopaedic implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] A preparation method of the above-mentioned orthopedic temporary implant, comprising the following steps:

[0036] S1. dissolving the chitosan quaternary ammonium salt in deionized water to obtain a chitosan quaternary ammonium salt aqueous solution with a concentration of 20-45 mg / mL;

[0037] S2. prepare respectively the inorganic salt aqueous solution of calcium and (NH 4 ) 2 HPO 4 aqueous solution, and the pH of the two groups of solutions was adjusted to 10-11 with ammonia water, and the molar ratio of calcium and phosphorus was 1.67, and (NH 4 ) 2 HPO 4 The aqueous solution is added to the calcium inorganic salt aqueous solution, and then the organic silicon quaternary ammonium salt is added. After mixing evenly, the hydrothermal treatment is carried out at 90-180°C for 4-16 hours in a high-pressure reactor, and then centrifuged, washed, and dried to obtain the quaternary ammonium salt Modified nano-hydroxyapatite;

[0038] In the hydrothermal process, the o...

Embodiment 1

[0044] An orthopedic temporary implant prepared by the following steps:

[0045] S1. dissolving the chitosan quaternary ammonium salt in deionized water to obtain a chitosan quaternary ammonium salt aqueous solution with a concentration of 30 mg / mL;

[0046] S2. preparation concentration is respectively the anhydrous calcium chloride aqueous solution of 45mg / mL and the (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH of two groups of aqueous solutions to 10 with ammonia water respectively, according to the molar ratio of calcium and phosphorus being 1.67, (NH 4 ) 2 HPO 4 The aqueous solution is added to the anhydrous calcium chloride aqueous solution, and then the molar ratio of the organic silicon quaternary ammonium salt to the calcium atom is 1:8, and the hexadecyltrimethoxysilane quaternary ammonium salt is added, and after stirring and mixing evenly, the mixed solution is Pour into a high-pressure reactor, hydrothermally treat at 120°C for 12 hours, then centrifug...

Embodiment 2-3

[0058] The orthopedic temporary implant provided in Example 2-3, its preparation method is compared with Example 1, the difference is that in step S2, the molar ratio of organosilicon quaternary ammonium salt to calcium atom is shown in Table 2, and other Embodiment 1 is basically the same and will not be repeated here.

[0059] The mechanical strength test result of table 2 embodiment 2-3

[0060]

[0061] It can be seen from Table 2 that with the increase of the molar ratio of organosilicon quaternary ammonium salt and calcium atom, and with the increase of the content of organosilicon quaternary ammonium salt, the mechanical strength of orthopedic temporary implants tends to increase gradually , this will be because during the growth process of hydroxyapatite, the organosilicon quaternary ammonium salt can be selectively adsorbed on the hydrophilic crystal surface of nano-hydroxyapatite, reducing its agglomeration, increasing the surface active point, thereby increasing ...

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Abstract

The invention provides a temporary orthopaedic implant and a preparation method thereof, and belongs to the technical field of medical materials. The temporary orthopaedic implant is injectable composite temperature-sensitive hydrogel which is composed of a chitosan quaternary ammonium salt, quaternary ammonium salt-modified nano-hydroxyapatite and an ampholytic surfactant. After the injectable composite temperature-sensitive hydrogel is injected into the human body, an electrostatic force is formed among quaternary ammonium salts on the surface of the chitosan quaternary ammonium salt and quaternary ammonium salts and phosphate on the surface of the quaternary ammonium salt-modified nano-hydroxyapatite through anions and cations of the ampholytic surfactant so as to obtain hydrogel with aporous three-dimensional cross-linked network structure. Through modification with quaternary ammonium salts, the temperature-sensitive hydrogel is formed mainly through the electrostatic interaction, the mechanical properties of the hydrogel is improved, and the hydrogel has good antibacterial properties; and the amino acid ampholytic surfactant is preferably used as a bridge in electrostatic crosslinking, good biocompatibility is achieved, and a through cross-linked network is formed, so that the mechanical properties are improved further.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an orthopedic temporary implant and a preparation method thereof. Background technique [0002] There are tens of millions of patients with bone defects worldwide every year due to fractures and improper treatment after fractures, severe trauma, infection, bone tumors and other reasons. Bone defect is a common disease, mainly due to local bone loss caused by trauma and disease (such as infection, tumor, etc.). Because of its high clinical incidence, there is still a lack of ideal treatment methods. One of the current problems. Although bone grafting (autologous bone grafting, allografting bone grafting) is a traditional treatment for repairing bone defects and has good curative effect, there are still obvious deficiencies and limitations. Therefore, it is urgent to seek ideal bone graft substitute materials. [0003] Some thermosensitive hydrogels have attracted inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/52A61L27/54A61L27/56
CPCA61L27/46A61L27/52A61L27/54A61L27/56A61L2300/208A61L2300/404A61L2300/626A61L2400/06A61L2430/02C08L5/08
Inventor 虞连奎
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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