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Phenolic acid compound, preparation method and application thereof

A compound and phenolic acid technology, which is applied in the field of medicine and achieves the effects of simple extraction and separation method, good α-glucosidase inhibitory activity, and simple and novel structure

Inactive Publication Date: 2020-06-19
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phenolic acid compound with two ester groups involved in the present invention and its activity have not been patented or reported in the literature so far.

Method used

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  • Phenolic acid compound, preparation method and application thereof
  • Phenolic acid compound, preparation method and application thereof
  • Phenolic acid compound, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of formula I compound:

[0031] The dried whole plant of Serpentis chinensis is used as raw material, heated and refluxed with 75% ethanol for 3 times, and the extraction time is 4, 3, 2 hours respectively, and concentrated to obtain extract-like ethanol extract. Suspend the ethanol extract in water to obtain a suspension, sequentially add petroleum ether, ethyl acetate, and n-butanol equal in volume to the suspension for extraction, concentrate each extraction solution to obtain an extract, and distill the ethyl acetate part through Silica gel column chromatography, gradient elution with dichloromethane-methanol solution with a volume ratio of 50:1-1:1, wherein the eluate with a ratio of dichloromethane-methanol of 5:1 was processed by Waters2545 automatic preparation High performance liquid chromatography, eluted with methanol-water solvent gradient with a volume ratio of 30:70-90:30 (0.3% trifluoroacetic acid) for 4 hours, and the eluted...

Embodiment 2

[0032] Embodiment 2: the pharmacological activity of formula I compound

[0033] 1. PNPG method to detect the inhibitory activity of the compound of formula Ⅰ to α-glucosidase

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Abstract

The invention belongs to the technical field of medicines, and relates to a phenolic acid compound, a preparation method and application thereof, particularly to a new phenolic acid compound extractedand separated from a whole balanophora involucrata plant, and a preparation method thereof, and application in preparation of an alpha-glucosidase inhibitor medicine. The structure of the compound isrepresented by a formula I in the specification.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a phenolic acid compound and its preparation method and application, in particular to a new phenolic acid compound extracted and separated from the whole plant of Serpentis chinensis and its preparation method and its preparation method. Use in alpha-glucosidase inhibitors. Background technique [0002] α-glucosidase concentrates on the brush border of the small intestine mucosa. After the human body eats, α-glucosidase will hydrolyze the carbohydrates in the food and hydrolyze them into glucose that can be absorbed by the human body and enter the blood circulation. cause blood sugar to rise. Therefore, the use of drugs to inhibit the activity of α-glucosidase is one of the main means to control postprandial blood sugar. α-glucosidase inhibitors are a new class of antidiabetic drugs, which have been widely used clinically. α-glucosidase inhibitors are a class of main drugs for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/84C07C67/48A61P3/10
CPCC07C69/84A61P3/10C07B2200/07
Inventor 贾景明阎婷魏江春
Owner SHENYANG PHARMA UNIVERSITY
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