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Improved process for extraction of cholesterol from fish oil waste residue

A technology of cholesterol and waste residue, which is applied in the fields of fat oil/fat refining, recovery/refining of fatty substances, fatty acid production, etc., and can solve the problems of low purity of total yield, multi-step cumbersome, large amount of solvents, etc.

Active Publication Date: 2020-06-19
FERMENTA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method described in WO'989 is a multi-step cumbersome solvent extraction method requiring large amounts of solvent
Overall yield (w / w compared to fish oil) and low purity

Method used

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  • Improved process for extraction of cholesterol from fish oil waste residue

Examples

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example 1

[0035] Example 1: Cholesterol from Fish Oil

[0036] 400 g of fish oil waste (containing 0.4-0.6 g of cholesterol (free and esterified form) per gram of fish oil waste) was suspended in 400 ml of methanol. 40 grams of sodium hydroxide and 1 gram of 4-dimethylaminopyridine were added and the reaction mass was refluxed for 1 hour. After 1 hour, methanol was distilled at 70-75°C. At 75°C, 600 ml of 25% sulfuric acid and 300 ml of water were added. 600 ml of 2-butanone were added and the reaction mass was stirred at 75°C for 30 minutes. The organic and aqueous layers were separated. The organic layer was washed with 3x100 ml saturated saline solution. 2-Butanone was evaporated at 90-95°C.

[0037] Further, 800ml of 2-butanone was added to the above reaction mass and cooled to 65-70°C. Add 190 grams of calcium bromide and heat at 65-70°C for 8 hours. The reaction was cooled to 30°C, filtered and washed with 100ml 2-butanone. The solid residue was suspended in 600 ml of meth...

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Abstract

The present invention discloses an improved process for extracting cholesterol in high yield and purity from fish oil waste residue. The obtained cholesterol of pharmaceutical grade is useful as a precursor for the preparation of vitamin D3.

Description

technical field [0001] The present invention relates to an improved process for the extraction of cholesterol from fish oil waste residues in high yield and purity. The pharmaceutical grade cholesterol thus obtained can be used as a precursor for the production of vitamin D3. Background technique [0002] Cholesterol, the IUPAC name is (3β)-cholestan-5-ethylenediamine-3-ol, and its systematic name is 2,15-dimethyl-14-(1,5-dimethylhexyl)tetracyclo[8.7 .0.02'7.011'15] Heptacosan-7-ethylenediamine-5-ol, a waxy substance found in certain foods and manufactured in the body, acts as a steroid hormone, bile and vitamin D bio Synthetic precursors. [0003] [0004] Cholesterol is found in egg yolks, organ meats, shrimp, squid, beef, pork, poultry, fish, lanolin, full-fat dairy products, butter, hard margarine, lard, coconut oil, ghee (clarified butter), vegetable ghee, in palm oil. These sources usually contain cholesterol in free form as well as in esterified form. The most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B3/02C11B11/00
CPCC11C1/025C11C1/08C07J9/00Y02W30/74C07C29/56
Inventor 阿努帕马·达察普拉桑特·纳格瑞贾格迪什·塔莫尔斯里纳特·特瑞维克拉姆加亚南·德冈加
Owner FERMENTA BIOTECH
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