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A kind of intrinsic self-healing zwitterionic hydrogel and preparation method thereof

A zwitterion and hydrogel technology, which is applied in the field of intrinsic self-repairing zwitterion hydrogel and its preparation, can solve the problems of high preparation cost, poor self-repair performance, and high cost, and achieve good biodegradability and preparation method The effect of simple process and low cost

Active Publication Date: 2022-07-05
QINGDAO ZHONGTENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this self-healing and degradable hydrogel still has some problems that cannot be ignored, such as poor self-healing performance, inconvenient preparation methods, and relatively high preparation costs.
For example, the introduced quadruple hydrogen bond unit based on ureidopyrimidinone unit UPy is often used in the existing hydrogel molecular structure, and its introduction method and preparation process are complex and tedious, and the cost is high.

Method used

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  • A kind of intrinsic self-healing zwitterionic hydrogel and preparation method thereof
  • A kind of intrinsic self-healing zwitterionic hydrogel and preparation method thereof
  • A kind of intrinsic self-healing zwitterionic hydrogel and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] (1) Preparation of zwitterion-functionalized polyasparagine derivatives

[0034]Dissolve 97g of polysuccinimide PSI (average molecular weight is about 7000g / mol) in 200g of DMF; add 30g of 5-methylcytosine, 20g of ethanolamine, 20g of N,N-dimethyl-1 , 3-propanediamine, react at 60 °C for 24 h for ring-opening reaction; then, add 24 g of 1,3-propane sultone, react at 38 °C for 8 h, and graft to the side of the polyasparagine derivative The tertiary amine group is subjected to quaternary amination reaction; after purification and drying, zwitterion-functionalized polyasparagine derivatives are obtained;

[0035] (2) Preparation of intrinsic self-healing zwitterionic hydrogels

[0036] Mix 100g of zwitterion-functionalized polyasparagine derivatives with 5000g of water, stir and dissolve evenly; add 5g of butanediamine, react at 66°C for 12h for cross-linking reaction, purify, and obtain intrinsic self-repairing zwitterions Hydrogels.

[0037] as attached figure 1 As ...

Embodiment 2

[0041] (1) Preparation of zwitterion-functionalized polyasparagine derivatives

[0042] Dissolve 97g of polysuccinimide PSI (average molecular weight is about 10000 g / mol) in 400g of DMSO; add 40g of 5-methylcytosine, 10g of isopropylamine, 15g of N,N-di Methyl-1,3-propanediamine was reacted at 40°C for 9h for ring-opening reaction; then, 18g of 1,3-propane sultone was added, reacted at 30°C for 18h, and grafted onto polyasparagine The pendant tertiary amine group of the derivative is subjected to quaternization reaction; after purification and drying, the zwitterion functionalized polyasparagine derivative is obtained;

[0043] (2) Preparation of intrinsic self-healing zwitterionic hydrogels

[0044] Mix 100g of zwitterion-functionalized polyasparagine derivatives with 500g of water, stir and dissolve evenly; add 6g of hexamethylenediamine, react at 70°C for 20h for cross-linking reaction, purify, and obtain intrinsic self-repairing zwitterions Hydrogels.

[0045] The pres...

Embodiment 3

[0048] (1) Preparation of zwitterion-functionalized polyasparagine derivatives

[0049] Dissolve 100 g of polysuccinimide PSI (average molecular weight is about 140,000 g / mol) in 100 g of DMF; add 10 g of 2-amino-4-hydroxy-6-methylpyrimidine, 10 g of arginine, 10 g of The N,N-dimethyl-1,3-propanediamine was reacted at 60°C for 24h for ring-opening reaction; then, 12g of 1,3-propane sultone was added, reacted at 40°C for 18h, and docked Branched to the pendant tertiary amine group of the polyasparagine derivative for quaternization reaction; after purification and drying, the zwitterion functionalized polyasparagine derivative is obtained;

[0050] (2) Preparation of intrinsic self-healing zwitterionic hydrogels

[0051] Mix 100g of zwitterion-functionalized polyasparagine derivatives with 1000g of water, stir and dissolve evenly; add 8g of triethylenetetramine, react at 60°C for 12h for cross-linking reaction, purify, and obtain intrinsic self-healing amphoteric ionic hydrog...

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Abstract

The invention discloses an intrinsic self-repairing zwitterionic hydrogel and a preparation method thereof. The present invention adopts polysuccinimide as the material main body, selects pyrimidine compounds, amine compounds, etc. to carry out ring-opening reaction and cross-linking reaction on polysuccinimide to prepare intrinsic self-repairing zwitterionic hydrogel materials. The zwitterionic hydrogel has self-healing function, biodegradability and good biocompatibility; the preparation method of the invention has simple process and low cost.

Description

technical field [0001] The invention relates to the field of hydrogel and preparation thereof, in particular to an intrinsic self-repairing zwitterionic hydrogel and a preparation method thereof. Background technique [0002] The disclosure of information in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] Hydrogel materials have important potential applications in flexible electronics, wearable devices, wound healing, and cartilage repair. For example, zwitterionic hydrogel materials, because their molecular segments have positive and negative charges at the same time, can combine with water molecules through ionic solvation, which can bind a large number of water molecules and keep water molecules in the material structure. Ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08G73/10
CPCC08J3/075C08J3/24C08G73/1092C08J2379/04
Inventor 刘云鸿彭新艳刘云晖
Owner QINGDAO ZHONGTENG BIOTECH
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