Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sericin hydrogel with self-healing function, and preparation method and applications thereof

A self-healing, hydrogel technology, applied in prosthesis, medical science, etc., can solve problems such as poor bone repair effect, achieve excellent self-healing function, simple and convenient operation, and mild reaction conditions

Active Publication Date: 2019-09-27
ZHEJIANG UNIV
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technical scheme needs to adjust the pH when synthesizing calcium phosphate bone cement, and there is a certain gap between the crystallinity and calcium-phosphorus ratio of apatite in the body, and the effect of bone repair may not be good.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sericin hydrogel with self-healing function, and preparation method and applications thereof
  • Sericin hydrogel with self-healing function, and preparation method and applications thereof
  • Sericin hydrogel with self-healing function, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Dissolve 6g sericin powder in 30mL dimethyl sulfoxide, add 4g carbonyldiimidazole to fully react, pour the mixed solution into 100mL, 600mg / mL adipic acid dihydrazide solution, fully react for 24h, and dialyze the reaction solution with 3500D The bag was dialyzed for 48 hours and freeze-dried to obtain aminated sericin.

[0050] Dissolve 3g of sodium alginate powder in 300mL of deionized water, add 3.24g of sodium periodate, react in the dark for 5 hours at room temperature, add 4.5mL of ethylene glycol to terminate the reaction for 1 hour, dialyze the reaction solution with a 3500D dialysis bag for 72 hours, and freeze-dry to obtain oxidized sodium alginate.

[0051] Dissolve aminated sericin and oxidized sodium alginate in deionized water respectively to make a solution with a concentration of 150 mg / mL, add hydroxyapatite powder with 40% sericin mass in the aminated sericin solution, Ultrasound for 30 minutes, mix the aminated sericin solution mixed with hydroxyapat...

Embodiment 2～3

[0069] The preparation process is the same as that in Example 1, except that the added amount of hydroxyapatite powder is replaced by 20% and 60% of the mass of sericin respectively.

[0070] After testing, the sericin hydrogels prepared in Examples 2 and 3 respectively have excellent self-healing properties, and the healing efficiency reaches 85.3% and 73% respectively after 12 hours.

[0071] After the compression test (the test conditions are the same as in Example 1), the maximum stresses of the hydrogels prepared in Examples 2 and 3 were respectively 134kPa and 84kPa, and the maximum strains were 52% and 59% respectively.

Embodiment 4

[0073] Dissolve 6g sericin powder in 30mL dimethyl sulfoxide, add 4g carbonyldiimidazole to fully react, pour the mixed solution into 100mL, 600mg / mL adipic acid dihydrazide solution, fully react for 24h, and dialyze the reaction solution with 3500D The bag was dialyzed for 48 hours and freeze-dried to obtain aminated sericin.

[0074] Dissolve 3g of sodium alginate powder in 300mL of deionized water, add 3.24g of sodium periodate, react in the dark for 5 hours at room temperature, add 4.5mL of ethylene glycol to terminate the reaction for 1 hour, dialyze the reaction solution with a 3500D dialysis bag for 72 hours, and freeze-dry to obtain oxidized sodium alginate.

[0075] Dissolve aminated sericin and oxidized sodium alginate in deionized water to prepare 150 mg / mL and 90 mg / mL solutions respectively, and add 40% hydroxyapatite powder of sericin mass to the aminated sericin solution, Ultrasound for 30 minutes, mix the aminated sericin solution mixed with hydroxyapatite and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Stressaaaaaaaaaa
Stressaaaaaaaaaa
Maximum stressaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a sericin hydrogel with self-healing function. The preparation method comprises following steps: 1, sericin is taken as a raw material to prepare aminated sericin; 2, sodium alginate is taken as a raw material to prepare oxidized sodium alginate; 3, the aminated sericin prepared in step 1, hydroxyapatite, and water are mixed so as to obtain a mixed solution; 4, the oxidized sodium alginate prepared in step 2 is mixed with water so as to obtain a solution, and the solution is mixed with the mixed solution obtained in step 3, and schiff base reaction is carried out so as to obtain the sericin hydrogel with self-healing function. The sericin hydrogel prepared using the preparation method possesses excellent self-healing function and mechanical properties, and is especially suitable to be used for promoting ossification.

Description

technical field [0001] The invention relates to the field of preparation of self-healing hydrogel, in particular to a sericin hydrogel with self-healing function, its preparation method and its application in promoting bone formation. Background technique [0002] Self-healing hydrogel is an emerging biomimetic material that mimics the self-healing mechanism of organisms after damage, and can automatically heal after the material is damaged. The healing mechanism of the self-healing hydrogel is mainly based on dynamic interactions such as hydrogen bonds, electrostatic interactions, dynamic metal coordination, hydrophobic interactions, supramolecular host-guest interactions, and imine bonds. When the internal structure of the gel is destroyed, The dynamic bonds at the damaged site recombine to enable the self-healing of the gel. Among them, the imine bond (also known as Schiff base) is a dynamic reversible chemical bond formed by the condensation of amines and active carbony...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/075C08L89/00C08L5/04C08K3/32C08H1/00C08B37/04A61L27/46A61L27/52
CPCA61L27/46A61L27/52C08B37/0084C08H1/00C08J3/075C08J2389/00C08J2405/04C08K2003/325C08L5/04C08L89/00
Inventor 杨明英段博
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com