Sericin hydrogel with self-healing function, and preparation method and applications thereof

Abstract

The invention discloses a preparation method of a sericin hydrogel with self-healing function. The preparation method comprises following steps: 1, sericin is taken as a raw material to prepare aminated sericin; 2, sodium alginate is taken as a raw material to prepare oxidized sodium alginate; 3, the aminated sericin prepared in step 1, hydroxyapatite, and water are mixed so as to obtain a mixed solution; 4, the oxidized sodium alginate prepared in step 2 is mixed with water so as to obtain a solution, and the solution is mixed with the mixed solution obtained in step 3, and schiff base reaction is carried out so as to obtain the sericin hydrogel with self-healing function. The sericin hydrogel prepared using the preparation method possesses excellent self-healing function and mechanical properties, and is especially suitable to be used for promoting ossification.

Description

technical field

[0001] The invention relates to the field of preparation of self-healing hydrogel, in particular to a sericin hydrogel with self-healing function, its preparation method and its application in promoting bone formation. Background technique

[0002] Self-healing hydrogel is an emerging biomimetic material that mimics the self-healing mechanism of organisms after damage, and can automatically heal after the material is damaged. The healing mechanism of the self-healing hydrogel is mainly based on dynamic interactions such as hydrogen bonds, electrostatic interactions, dynamic metal coordination, hydrophobic interactions, supramolecular host-guest interactions, and imine bonds. When the internal structure of the gel is destroyed, The dynamic bonds at the damaged site recombine to enable the self-healing of the gel. Among them, the imine bond (also known as Schiff base) is a dynamic reversible chemical bond formed by the condensation of amines and active carbony...

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