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Intracranial drug delivery material and method

A technology of water-soluble polymers and medical devices, which can be used in drug delivery, pharmaceutical formulations, catheters, etc., and can solve problems such as difficulties

Inactive Publication Date: 2020-06-26
BIOTRONIK AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, using Wafers are not without potential complications, as the physical presence of the wafer has been linked to difficulties in subsequent commonly used MRI activities (Colen, R.R. et al., World J. Radiol. 3(11), 2011, 266-272) and Associated with surgery-related adverse events and local toxicity (Chowdhary S.A., et al., J. Neurooncol122, 2015, 367-382)

Method used

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  • Intracranial drug delivery material and method
  • Intracranial drug delivery material and method
  • Intracranial drug delivery material and method

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Embodiment Construction

[0032] As used herein, the term "macrocyclic triene immunosuppressive compound" includes rapamycin (sirolimus), everolimus, zotarolimus, biolimus, Novolimus, myolimus, temsirolimus and rapamycin derivatives described in the present invention.

[0033] The present invention provides devices and methods that can accommodate the treatment of primary brain tumors in individuals. The medical device of the present invention provides a balloon catheter having a first coating and a second coating.

[0034]Preferably, said first coating is composed of a water soluble material and said first coating is formed on the surface of said medical device, preferably a balloon catheter. The first coating is preferably applied by dip coating, wherein the medical device, preferably a balloon catheter, is placed in a solution comprising the water soluble polymer, which solution is applied to the medical device. on the surface of the device. Other suitable methods such as spraying or applying the...

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Abstract

The present application relates generally to the field of minimally invasive delivery of therapeutic agents. In particular, the present invention provides materials and methods for minimally the invasive targeted delivery of the agents, such as drugs, penetrants, blood barrier enhancers or other compounds to the specific localized brain regions by using the delivery balloon catheters.

Description

technical field [0001] The present application relates generally to the field of minimally invasive delivery of therapeutic agents. In particular, the present invention provides materials and methods for the minimally invasive targeted delivery of agents, such as drugs, osmotic agents, blood barrier enhancers, or other compounds, to specific local brain regions through the use of delivery balloon catheters. Background technique [0002] The global incidence of primary malignant brain tumors and other central nervous system (CNS) tumors was 3.4 per 100,000 people in 2012, or a total of more than 250,000 for the same year. The incidence is higher in more developed countries (GLOBOCAN 2012v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet], International Agency for Research on Cancer; 2013). Glioblastoma multiforme (GBM) is the most common and deadly primary brain tumor and accounts for 12% to 15% of all intracranial tumors (U.S. National Brain T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/16A61K9/00C08L89/00
CPCA61L29/085A61L29/16A61K9/0085C08L89/00A61L2300/416A61L2300/608A61L2420/08A61L2300/802A61K31/436
Inventor R.E.贝茨
Owner BIOTRONIK AG
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