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Application of SDHC subunit genetically differentiated by fusarium as drug target resource in drug research and development

A technology of genetic differentiation and Fusarium, applied in the direction of biochemical equipment and methods, microbiological determination/inspection, etc., can solve problems affecting grain quality, wheat yield and quality decline, endangering human and animal health, etc.

Active Publication Date: 2020-07-03
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wheat head blight not only causes the yield and quality of wheat to decline, but also mycotoxins produced by pathogens infecting wheat grains will accumulate in wheat grains and affect the quality of grains, and in severe cases endanger the health of humans and animals

Method used

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  • Application of SDHC subunit genetically differentiated by fusarium as drug target resource in drug research and development
  • Application of SDHC subunit genetically differentiated by fusarium as drug target resource in drug research and development
  • Application of SDHC subunit genetically differentiated by fusarium as drug target resource in drug research and development

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1 Materials and methods

[0015] 1.1 Test strains

[0016] Fusarium asiatica collected from wheat scab-occurring plots in Jiangsu Province was named Fusarium asiatica 2021.

[0017] 1.2 Reagents

[0018] 1.2.1 Drugs to be tested

[0019] 98% Carboxin (Swiss Syngenta), 98% boscalid (Pyridylamine, Jiangxi Zhengbang Biochemical Co., Ltd.), 96% fluopyram (Fluoropylamide, Bayer) ), 99.1% Fluoropylamide (Fluoropylamide, Syngenta, Switzerland) were prepared with methanol into a mother solution of 10000 μg / mL.

[0020] 1.2.2 Test reagents and kits

[0021] Reagents such as restriction endonuclease and DIG high prime DNA labeling and detection starter kitⅠ (DIG kit) were purchased from TaKaRa Company, Gel Extraction Kit (200) kit was purchased from OMEGA Company, Phanta Max SuperFidelity DNA Polymerase, 2×Taq Plus Mix II was purchased from Novozyme, Hygeromycin was purchased from Solarbio, 5-Fluoro-2'-deoxyuridine was purchased from Fluka, Maker was purchased from TRAN, and...

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Abstract

The invention discloses application of an SDHC subunit genetically differentiated by fusarium as a drug target resource in drug research and development. The application shows that SDHC1 gene regulation and control on drug resistance of a succinate dehydrogenase inhibitor bactericide and SDHC2 gene regulation and control on sensitivity of the succinate dehydrogenase inhibitor bactericide provide atheoretical basis for revealing drug resistance research of the fusarium on a succinate dehydrogenase inhibitor and action mechanism research of the succinate dehydrogenase inhibitor on the fusarium,and provide important theoretical data for drug research and development with the SDHC1 gene and / or the SDHC2 gene as a drug target.

Description

technical field [0001] The invention relates to the fields of drug targets and drug research and development, and specifically discloses the use of Fusarium genetically differentiated SDHC subunits as drug target resources in drug research and development. Background technique [0002] Scab is one of the important diseases that occur in wheat, and it occurs seriously in the Jianghuai River Basin, southwest winter wheat region and northeast spring wheat region in my country. The pathogen that causes wheat head blight is mainly a complex population of Fusarium graminearum and Fusarium asiaticum as the dominant species, and its behavior is Gibberelllazeae. Wheat head blight not only causes the yield and quality of wheat to decline, but also mycotoxins produced by pathogens infecting wheat kernels will accumulate in wheat kernels and affect the quality of grains, and even endanger the health of humans and animals in severe cases. Effective measures to control wheat head blight ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/6876
CPCC12Q1/689C12Q1/6876C12Q2600/106
Inventor 周明国段亚冰陈长军赵婳婳卢飞毕莲玉李美霞
Owner NANJING AGRICULTURAL UNIVERSITY
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