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A preparation method of magnetic microspheres with uniform particle size

A magnetic microsphere, uniform technology, applied in the direction of microsphere preparation, microcapsule preparation, inductor/transformer/magnet manufacturing, etc., can solve the difficulty of obtaining magnetic microspheres with uniform particle size, uneven particle size of polymer The problem of uneven distribution of materials can achieve the effect of avoiding the impurity of magnetic microspheres, wide adjustable range of particle size and uniform particle size

Active Publication Date: 2022-03-04
BEAVERNANO TECH
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Problems solved by technology

This method is simple and easy, but the distribution of magnetic materials in the polymer matrix is ​​uneven, and the particle size of the formed polymer microspheres is not uniform, so it is difficult to obtain magnetic microspheres with uniform particle size.
[0008] Chinese patent CN 108129614 A is a magnetic microsphere and its preparation method and application. Firstly, a latex cue ball is synthesized, and then a brush-like polymer is grafted on the surface by atom transfer radical polymerization. The structure is an obvious two-layer structure. There are many synthesis steps, and the synthesis requires high anaerobic conditions

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  • A preparation method of magnetic microspheres with uniform particle size

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[0031] A method for preparing magnetic microspheres with uniform particle size, the preparation method consists of two steps;

[0032] Step 1, preparation of polymer microspheres: add mixed monomer 1 and initiator to the solvent to carry out the first-stage reaction, and then add mixed monomer 2 to react after the first-stage reaction is completed to obtain the polymer as the core Microspheres; the mixed monomer is a mixture of polymer monomers and crosslinking agents, and the polymer monomers include methacrylic acid, glycidyl methacrylate, styrene, and other materials that can be directly formed with iron ions A coordination bond or a monomer that can form a coordination bond with iron ions after chemical modification; the mixed monomer 2 is a mixture of the polymer monomer and a crosslinking agent;

[0033] Step 2, preparation of magnetic microspheres with uniform particle size: mix the polymer microspheres prepared in step 1 with ferric salt and ferrous salt in the water p...

Embodiment 1

[0038] Step 1: Weigh 0.2g of benzoyl peroxide, dissolve it in 50-200mL of acetonitrile, add 3mL of methacrylic acid, 3mL of divinylbenzene, pass through nitrogen for 30 minutes to deoxidize, and then immerse in a 70-100℃ oil bath to react O .5-5 hours, then dropwise add the mixed solution of methacrylic acid 5mL and divinylbenzene 1mL with the speed of 2 milliliters / hour, react 1-3 hour again after dropping, obtain poly(divinylbenzene-methanol Acrylic acid) microspheres.

Embodiment 2

[0040] Step 1: Weigh 0.2g of benzoyl peroxide, dissolve it in 50-200mL of acetonitrile, add 3mL of glycidyl methacrylate, 3mL of divinylbenzene, blow nitrogen for 30 minutes to deoxidize, and then immerse in an oil bath at 70-100°C React in medium for 0.5-5 hours, then add dropwise a mixture of glycidyl methacrylate 5mL and divinylbenzene 1mL at a rate of 2 ml / hour, and react for 1-3 hours after the addition is complete. After the reaction was completed, the obtained polymer microspheres were cleaned by centrifugation with ethanol, then dispersed in ethanol, 5 mL of ethylenediamine was added, and then the temperature was raised to 70° C. for reflux reaction overnight, and finally the aminated poly(divinylbenzene) obtained by centrifugation was cleaned with ethanol. - glycidyl methacrylate) microspheres.

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Abstract

The invention provides a method for preparing magnetic microspheres with uniform particle size, the magnetic microspheres include a polymer microsphere core and a magnetic material layer, and the preparation method is composed of two steps; the first step is the polymer microsphere core The preparation of the second step is the preparation of magnetic microspheres with uniform particle size. The present invention adopts polymer microspheres with high cross-linking degree of inner core-low cross-linking degree of shell or zero cross-linking as a template, and deposits a magnetic material layer on the surface of polymer microspheres by co-precipitation method to prepare uniform particle size and high Magnetic microspheres loaded with magnetic materials. The preparation process and process involved in the present invention are simple, the magnetic material content of the obtained magnetic microspheres is high, the magnetic response speed is fast, and the particle size is uniform, the particle size can be adjusted in a wide range, and the preparation process does not contain free iron oxide nanoparticles particles, without the need for subsequent tedious washing and purification processes.

Description

technical field [0001] The invention relates to the technical field of microsphere synthesis, in particular to a method for preparing magnetic microspheres with uniform particle diameters. Background technique [0002] Magnetic microspheres refer to composite material microspheres with a size of submicron to micron and magnetic responsiveness, generally composed of a magnetic material part and a non-magnetic material part, and the magnetic material part is generally Fe 3 o 4 or γ-Fe 2 o 3 , or other types of ferrite materials, non-magnetic materials include organic materials or inorganic materials. [0003] Magnetic microspheres are widely used in the purification of in vitro diagnostic reagents or biological samples, because magnetic separation has the advantages of simple separation method, fast separation speed, easy automation and high-throughput processing of samples. In the application of in vitro diagnosis, there are high requirements on the particle size uniformi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02B01J13/14H01F41/02
CPCB01J13/02B01J13/14H01F41/0253
Inventor 任辉吴少珏
Owner BEAVERNANO TECH
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