Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation of nucleophilic phosphorene compound

A technology of nucleophilic phosphorene and compound, which is applied in the field of preparation of nucleophilic phosphorene compounds, and can solve the problems that phosphorene cannot be synthesized chemically and has poor reaction selectivity.

Pending Publication Date: 2020-07-10
NANKAI UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since free phosphorene is unstable at room temperature and has poor reaction selectivity, this type of phosphorene cannot be really applied to synthetic chemistry

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation of nucleophilic phosphorene compound
  • Preparation of nucleophilic phosphorene compound
  • Preparation of nucleophilic phosphorene compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Precursor compound 1 (42 mg, 0.1 mmol) and crown ether 12-crown-4 (20 μl, 0.12 mmol) were placed in a Shrek bottle, 1.5 ml of diethyl ether was added, and freshly prepared diisopropyl Lithium amide was stirred at low temperature for 2 hours, and the solvent was dried with a vacuum pump. The crude product was washed with hexane (1ml*3), and then recrystallized with ether solvent at low temperature to obtain 28 mg of the target product with a yield of 73%.

Embodiment 2

[0012] Precursor compound 2 (43 mg, 0.1 mmol) and crown ether 18-crown-6 (32 mg, 0.12 mmol) were placed in a Shrek bottle, 2.0 ml of ether was added, and potassium tert-butoxide (13 mg, 0.12mmol), stirred at low temperature for 2h, dried the solvent with a vacuum pump, washed the crude product with hexane (1ml*3), and recrystallized with ether solvent at low temperature to obtain 27mg of the target product with a yield of 69%.

Embodiment 3

[0014] Precursor compound 3 (45mg, 0.1mmol) and crown ether 15-crown-5 (24μl, 0.12mmol) were placed in a Shrek bottle, 1.5ml of ether was added, and bis-(trimethylsilyl) was added at -78°C Base) sodium amide (22mg, 0.12mmol), stirred at low temperature for 2h, dried the solvent with a vacuum pump, washed the crude product with hexane (1ml*3), and recrystallized with ether solvent at low temperature to obtain 27mg of the target product, with a yield of 66 %.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a nucleophilic phosphorene compound, and belongs to the field of chemical medicine preparation. Phosphorene (RP) is a monovalent phosphorus compound with a six-electron structure. As a phosphorus analogue of carbene, phosphorene is always an important organophosphorus reagent. Due to the instability of free phosphorene, chemists synthesize Lewis acidand Lewis alkali complexes of phosphorene by utilizing the dual characteristics of phosphorene molecules. The two types of complexed phosphorene are higher in stability and easier to regulate and control in reactivity, especially nucleophilic phosphorene coordinated by Lewis alkali. According to the invention, the nucleophilic phosphorene compound can be obtained with high yield by using the hydride of precursor phosphorus to react with alkali at low temperature in the presence of crown ether / cryptand. The obtained target product can be used as a catalyst for various catalytic reactions.

Description

technical field [0001] The invention discloses a preparation method of nucleophilic phosphorene compounds, which belongs to the field of chemical medicine preparation. Background technique [0002] Phosphorene (RP) is a class of monovalent phosphorus compounds with a six-electron structure. As a phosphorus analog of carbon carbene, phosphorene has been widely concerned by organic chemists and is an important organophosphorus reagent. Due to the instability of free phosphorene at room temperature and poor reaction selectivity, this kind of phosphorene cannot be really applied in synthetic chemistry. So chemists took advantage of the amphoteric characteristics of phosphorene molecules to synthesize Lewis acid complexes and Lewis base complexes of phosphorene. Compared with free phosphorene, these two types of complexed phosphorenes have higher stability and easier regulation of reactivity. Therefore, these two types of phosphorene have been the main body of phosphorene chem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07F9/6587B01J31/02
CPCB01J31/0267B01J31/0271C07F9/6587
Inventor 段莉莉贾亦博
Owner NANKAI UNIV
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement