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Construction method and application of fingerprint of Xiaoerzhike syrup

A technology for children's cough syrup and construction method, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of lack of quality control of orange peel and platycodon grandiflorum, and failure to achieve the quality evaluation of preparations, so as to save detection time, reduce dosage, and separate good effect

Active Publication Date: 2022-08-05
YAAN THREE NINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current quality control method for children's cough syrup in the "Chinese Pharmacopoeia" is mainly reflected in the content control of licorice and ammonium chloride, but lacks the quality control of orange peel and bellflower, which cannot achieve the purpose of comprehensive quality evaluation of the preparation

Method used

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  • Construction method and application of fingerprint of Xiaoerzhike syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (A) Provide test solution: Take a child to relieve cough syrup, take 1ml to a 10ml meter bottle, add methanol to the scale, shake it, filter, and collect the continuous filtrate as the test solution.

[0074] (b) Provide reference solution: Take the control of ammonium glycotate, the controlling product of the orange pepperin, the orange -side saponin D control product, and the precision is precise. Add 50 % methanol to the mixture of 50 μg, 50 μg, and 20 μg per LML, respectively. The solution is obtained.

[0075] (C) Precision absorbing the reference solution and the test product solution of 1 μL, inject ultra -high -efficiency liquid chromatographs to perform ultra -high -efficiency liquid chromatography analysis, obtain the fingerprint diagram of references and children's cough syrup, ultra -high -efficiency liquid chromatography analysis The condition is:

[0076] Taking eighteen alkyr sirrifice -alkyne bonds silicone as the filling agent (the length of the column is 1...

Embodiment 2

[0086] Take another 999 -branded children's cough syrup for different specifications produced in 2019. Compared with the comparison of the comparison fingerprint map according to the above chromatographic conditions. As a result, see Table 1, the similarity is between 0.91 ~ 0.96, indicating that this is this. The fingerprint diagram of the invention can be used to control the quality control of children's cough syrup.

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Abstract

The present invention provides a method and application of a pediatric cough syrup fingerprint map, which involves the field of drug analysis technology, including using ultra -high -efficiency liquid chromatography to analyze the samples to be tested, obtaining a chromatography peak of 0 to 15min, and obtaining a pediatric cough syrup fingerprint map.; Among them, the analysis conditions of ultra -high -efficiency liquid chromatography are: flow phase A includes eluing buffer, flow phase B includes acetylene; detection wavelength: 0-12min is 208-212nm; 12-15min is 235-239nm; flow phase A is in the0 ~ 15min drop from 95 ± 5 % V / V to 5 ± 5 % V / V; flow phase B rose from 5 ± 5 % V / V to 95 ± 5 % V / V from 5 ± 5 % V / V.The constructing method of this fingerprint graphic can also identify a variety of chemical ingredients in children's cough syrup at the same time, effectively saving testing time, and is of great significance for comprehensively evaluating the quality of children's cough syrup.

Description

Technical field [0001] The invention involves the field of drug analysis technology, especially the construction method and application of a pediatric cough syrup fingerprint map. Background technique [0002] Pediatric cough syrup is a Chinese medicine prescription, which is a red -brown semi -transparent viscous liquid with sweet taste. The main components of children's cough syrup include licorice flowing, bellflower flowing, ammonium chloride and orange peel. Licorice is the root and rhizomes of the bean -based plant licorice. It has the effects of expectorant and cough, antitussive, heat -clearing and detoxifying, nourishing the spleen and qi, and relieving pain. Promote lungs, expectorant, throat, pus, qi and blood, smooth qi and qi, qi and blood circulation, relieve panic, and nourish qi. Qi stagnation, abdominal distension, weak spleen and stomach, indigestion, sputum dampness, nausea and vomiting; ammonium chloride can stimulate the mucous membrane to increase the amount...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/32G01N30/34G01N30/74G01N30/86
CPCG01N30/02G01N30/06G01N30/32G01N30/34G01N30/74G01N30/8631G01N30/8686G01N2030/324
Inventor 袁海英蔡帮军侯新莲史琳莉
Owner YAAN THREE NINE PHARMA
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