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Adenosine receptor antagonist and medicine for treating bladder and urinary dysfunction

A technology for adenosine receptors and dysfunction, applied in drug combinations, urinary system diseases, pharmaceutical formulations, etc., can solve problems that hinder research on regulating urinary function, achieve the effect of reducing urination frequency and increasing bladder capacity

Inactive Publication Date: 2020-07-14
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This seriously hinders the research on the regulation of urinary function by corresponding drugs.

Method used

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  • Adenosine receptor antagonist and medicine for treating bladder and urinary dysfunction
  • Adenosine receptor antagonist and medicine for treating bladder and urinary dysfunction
  • Adenosine receptor antagonist and medicine for treating bladder and urinary dysfunction

Examples

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Embodiment Construction

[0028] The invention includes a method for regulating the contractility of bladder smooth muscle, the method comprising injecting an effective dose of an adenosine receptor agonist into a mammal in need, and the agonist is a novel A2b adenosine receptor agonist UroA002.

[0029] The present invention also relates to a method for evaluating A2b adenosine receptor agonists for regulating bladder and urinary dysfunction in mammals:

[0030] (1) Determine the regulatory effect of A2b adenosine receptor agonists such as UroA002 on the contractility of mammalian bladder smooth muscle using isolated smooth muscle;

[0031] (2) Subcutaneously inject the novel A2b adenosine receptor agonist UroA002 directly into mammals such as mice to observe its regulating effect on bladder function in vivo.

[0032] (3) Gavage the novel A2b adenosine receptor agonist UroA002 to mammalian mice to observe its regulating effect on bladder function in vivo.

[0033] Taking mice as the experimental obje...

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PUM

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Abstract

The invention discloses an application of an adenosine receptor antagonist in preparation of a medicine for treating bladder and urinary dysfunction of mammals. The adenosine receptor antagonist can effectively increase bladder capacity and reduce urination frequency.

Description

technical field [0001] The present invention relates to the application of adenosine receptor agonist in the preparation of medicine for treating bladder and urinary dysfunction, and the method for evaluating the regulation of mammalian bladder and urinary dysfunction by adenosine receptor agonist. Background technique [0002] Urinary bladder dysfunction such as urinary frequency, urgency, nocturia, dysuria, overactive bladder syndrome, urinary incontinence, interstitial cystitis, drug-induced cystitis (ketamine cystitis), etc. affecting at least 50% of > 40 year old crowd. Current treatment options are limited and include: fluid intake control, drug control, use of adult diapers, and surgery. As far as drugs are concerned, there are currently: 1. First-line anticholinergic drugs, but the current oral dosage forms have limited curative effect and large side effects (most of them are finally abandoned); 2. Recently, β3 receptor agonists have been used for treatment, whic...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61P13/10A61P13/02A61P13/00
CPCA61K31/4439A61P13/00A61P13/02A61P13/10
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