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Preparation process of high-purity and high-transmittance L-threonine

A preparation process and threonine technology, applied in the field of amino acid preparation, can solve problems such as the lack of a reasonable and effective implementation process

Inactive Publication Date: 2020-07-14
石家庄市冀荣药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But how to further improve the purity and light transmittance of L-threonine, there is no reasonable and effective implementation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] A preparation process of high-purity and high-transmittance L-threonine, adding feed-grade crude L-threonine into purified water and heating to 65-75°C to dissolve it; adding EDTA-disodium; dissolving the dissolved solution through After the medicinal activated carbon is adsorbed, it is filtered; after the filtration, the solution is slowly crystallized with cold water and stirring at a constant speed. The crystallization solution was centrifugally filtered to obtain white crystals, and the crystals were washed with purified water. The washed crystals are dried at a temperature of 70-85° C. to obtain pure L-threonine.

[0016] EDTA is used to chelate the metal ions in feed-grade L-threonine, so that the metal ions in the solution are reduced, causing the protein complex to become unstable, and then separated into protein monomers, which is convenient for activated carbon adsorption and purification. Add EDTA - The acidic effect of disodium in water further increases th...

Embodiment 1

[0019] Add 300g of crude feed-grade L-threonine with a content of 98% and a light transmittance of 52% into 1200ml of purified water and heat it to 65-75°C to dissolve it; use 5g of EDTA-disodium to keep it warm for 30 minutes; pass the dissolved solution through After 5g of medicinal activated carbon is adsorbed, it is filtered; after filtration, the solution is slowly crystallized with cold water and stirring at a constant speed. The crystallization solution was centrifugally filtered to obtain white crystals, and the crystals were washed with purified water. Dry the washed crystals at a temperature of 70-85°C to obtain pure L-threonine with a purity of 99.81% and a light transmittance of 99.8%.

[0020] Implementation column 2

[0021] Add 300g of crude feed-grade L-threonine with a content of 98% and a light transmittance of 52% into 1200ml of purified water and heat to 65-75°C to dissolve it; use 2 g of EDTA-disodium to incubate for 30 minutes; After the dissolved solut...

Embodiment 3

[0023] Add 300g of crude feed-grade L-threonine with a content of 98% and a light transmittance of 52% into 1200ml of purified water and heat it to 65-75°C to dissolve it; use 1g of EDTA-disodium to keep it warm for 30 minutes; pass the dissolved solution through After 5g of medicinal activated carbon is adsorbed, it is filtered; after filtration, the solution is slowly crystallized with cold water and stirring at a constant speed. The crystallization solution was centrifugally filtered to obtain white crystals, and the crystals were washed with purified water. Dry the washed crystals at a temperature of 60-70°C to obtain pure L-threonine with a purity of 99.79% and a light transmittance of 99.7%.

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Abstract

The invention discloses a preparation process of high-purity and high-light-transmittance L-threonine, which comprises the following specific steps: a, dissolving: adding a feed-grade L-threonine crude product into purified water for dissolving, and adding EDTA-disodium; b, decolorizing and filtering: adsorbing the dissolved solution with activated carbon, and performing filtering; c, crystallizing and centrifuging: slowly crystallizing the filtered filtrate while stirring at a constant speed; d, centrifuging and washing: centrifugally filtering the crystallization liquid to obtain white crystals, and washing the crystals with purified water; and e, drying: drying the washed crystal at the temperature of 70-85 DEG C to obtain a pure product L-threonine. Compared with the prior art, the preparation process has the advantages that the production time is shortened, and the efficiency is improved; and through the preparation process, the purity and the light transmittance of the prepared L-threonine are remarkably improved.

Description

technical field [0001] The invention relates to the technical field of preparation methods of amino acids, in particular to a preparation process of high-purity and high-transmittance L-threonine. Background technique [0002] L-threonine is an essential amino acid. Threonine is mainly used in medicine, chemical reagents, food fortifiers, feed additives, etc. Threonine is white orthorhombic or crystalline powder, odorless and slightly sweet. Melts and decomposes at 253°C, soluble in water at high temperature, solubility at 25°C is 20.5g / 100ml, isoelectric point 5.6, insoluble in ethanol, ether and chloroform. [0003] L-threonine is an essential amino acid. Threonine is mainly used in medicine, chemical reagents, food fortifiers, feed additives, etc. In particular, the amount of feed additives is increasing rapidly. It is often added to the feed of immature piglets and poultry. It is the second limiting amino acid in pig feed and the third limiting amino acid in poultry fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/22C07C227/40C07C227/42
CPCC07C227/40C07C227/42C07B2200/07C07C229/22
Inventor 苏兆宁韩建峰巴红娟张伟力韩建磊李静静
Owner 石家庄市冀荣药业有限公司
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