The invention relates to the technical field of fruit wine, in particular to a preparation method of pumpkin fruit wine, which comprises the following steps: selecting mature pumpkins with peels, washing, then peeling the pumpkins, removing pumpkin pulp, putting the diced pumpkin pulp into salt water, washing, draining for later use, putting the pumpkin pulp into a crusher, crushing, and crushing for later use; after crushing, separating fruit juice from pumpkin residues, squeezing the pumpkin residues through a continuous screw squeezer to obtain juice in pulp, and collecting the fruit juice for later use; the preparation method of the pumpkin fruit wine has the advantages that the raw materials can be fully utilized, and industrialization is easy, so that the pumpkin fruit wine product is high in nutritive value and good in taste, the commercial value of pumpkins can be fully reflected, meanwhile, the pumpkin fruit wine has the effects of moistening the lung, tonifying qi, reducing phlegm, expelling pus, expelling parasites, detoxifying, treating cough, relieving asthma, treating pulmonary abscess and constipation, inducing diuresis, beautifying the features and the like, and the pumpkin fruit wine is suitable for large-scale popularization and application. The pumpkin fruit wine can effectively supplement body nutritional ingredients and improve the disease resistance of the body.