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Method for determining four preservatives in cosmetics

A method of determination and technology of cosmetics, applied to the determination of four preservatives in cosmetics, the application field of extraction and trace determination, to achieve the effect of improving separation and extraction effect, high enrichment factor and good recovery rate

Pending Publication Date: 2020-07-31
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most IL-DLLME methods have a centrifugation step, which is an additional time-consuming step in the extraction process

Method used

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  • Method for determining four preservatives in cosmetics
  • Method for determining four preservatives in cosmetics
  • Method for determining four preservatives in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1. Instruments and reagents

[0054] 1.1 Instruments:

[0055] Agilent 1200 high performance liquid chromatography diode array detector (DAD), electronic analytical balance, kq5200 ultrasonic cleaning machine (Kunshan Ultrasonic Instrument Co., Ltd.), Fourier transform infrared spectroscopy (German Bruker IFS-66FTIR), vibrating sample magnetometer ( US Quantum Design MPMS VSM), Scanning Electron Microscope (US FEI Helios Nanolab 600iSEM), Transmission Electron Microscope (JEOL Ltd. JEM-2100F TEM)

[0056] 1.2 Reagent

[0057] Deionized water (Wahaha Group Co., Ltd.), hydrochloric acid, sodium hydroxide and absolute ethanol (Tianjin Hengxing Chemical Reagent Manufacturing Co., Ltd.), chromatographically pure methanol, acetonitrile, acetone (Shandong Yuwang Industrial Co., Ltd.), chlorine hexahydrate FeCl 3 ·6H 2 O, purity 99%) and ferrous chloride tetrahydrate (FeCl 2 4H 2 O, purity 99%) (Alan Biotechnology Co., Ltd.), graphene oxide (Nanjing Jicang Nano Technology...

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Abstract

The invention belongs to the technical field of detection of preservatives in cosmetics, and relates to a method for determining four preservatives in cosmetics, in particular to application of selective extraction and trace determination of benzoate compounds in cosmetics by combining two-step extraction technologies of ionic liquid dispersion liquid-liquid microextraction and magnetic solid-phase extraction with a high-performance liquid phase. The method comprises the following steps: (1) synthesizing a magnetic nano material; (2) pretreating a cosmetic sample; (3) performing an ionic liquid dispersion liquid-liquid microextraction process; (4) performing a magnetic solid-phase extraction, enrichment and concentration process; and (5) determining the content of p-hydroxybenzoate compounds in the eluent by high performance liquid chromatography. Magnetic nanoparticles are dropwise added into a sample solution, a target analyte is adsorbed through hydrophobic interaction, then a magnetic material is separated through a magnet, and eluent is introduced into an instrument for analysis. The method is simple, convenient, sensitive, high in recovery rate and good in repeatability, andcan be applied to detection of preservatives of cosmetics.

Description

technical field [0001] The invention belongs to the technical field of preservative detection in cosmetics, and relates to a method for measuring four kinds of preservatives in cosmetics, in particular to the use of ionic liquid dispersion liquid-liquid micro-extraction and magnetic solid-phase extraction (DLLME-MSPE) two-step extraction technology combined with high-efficiency liquid phase (HPLC) the application of the selective extraction and trace determination of benzoate compounds in cosmetics. Background technique [0002] Most of the active ingredients in cosmetics are nutritional ingredients, which are prone to corruption due to microbial contamination, resulting in quality deterioration. Preservatives can effectively prevent this from happening. Benzoic acid ester compounds are esters formed by the reaction of benzoic acid compounds and alcohols. They are widely used in food, medicine and cosmetics due to their advantages such as broad antibacterial spectrum, high s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/36G01N1/40
CPCG01N30/02G01N30/06G01N30/36G01N30/34G01N1/405G01N2030/027G01N2030/062
Inventor 赵龙山索玲喆王洋高珣
Owner SHENYANG PHARMA UNIVERSITY
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