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Composition for treating acute pancreatitis, and application thereof

A technology of composition and application, which is applied in the field of medicine, can solve problems such as the need to improve the therapeutic effect, and achieve important medical prospects, economic value, and better effect

Active Publication Date: 2020-08-07
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its therapeutic effect still needs to be improved

Method used

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  • Composition for treating acute pancreatitis, and application thereof
  • Composition for treating acute pancreatitis, and application thereof
  • Composition for treating acute pancreatitis, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Therapeutic effect of the composition of the present invention on acute pancreatitis in rats

[0022] (1) Experimental method

[0023] Modeling: Take 40 SPF grade male SD rats (210-250g). SD rats in each group were anesthetized, skin-prepared and disinfected, and a 2-3 cm transverse incision was made in the upper abdomen at 1-2 cm below the xiphoid process. Determine the liver, stomach, and spleen, find the duodenum by following the stomach, find the pancreas between the duodenal mesentery and the spleen at the back of the stomach, and find the opening of the transparent bile-pancreatic duct and the duodenum at the opening along the inner side of the duodenum. Intestinal big nipples. The common hepatic duct was ligated with an arterial clip near the hilum, and then the needle was advanced obliquely from the side of the duodenum and the direction of the needle was adjusted so that it could enter the bile-pancreatic duct. Slowly inject 2.5% sodium taurochol...

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PUM

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Abstract

The invention discloses a composition for treating acute pancreatitis, and application thereof. The composition comprises (a) octreotide and (b) WX-UK1 or WX-671, the content of serum amylase can be effectively reduced, and the composition has a synergistic treatment effect on acute pancreatitis. The composition for treating acute pancreatitis provided by the invention is better in effect and hasimportant medical prospect and economic value.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a composition for treating acute pancreatitis and its application. Background technique [0002] Acute pancreatitis is mainly due to the self-digestion of the pancreas by pancreatic enzymes and the digestion of its surrounding tissues, resulting in a series of organ dysfunction. features. There are many causes, common ones are gallstone disease, heavy drinking and overeating. The fatality rate of acute pancreatitis is about 10%, and almost all the fatal cases are the first attack. The presence of respiratory insufficiency or hypocalcemia indicates a poor prognosis. The fatality rate of severe necrotizing pancreatitis is 50% or higher, and surgical treatment can reduce it to about 20%. [0003] Most acute pancreatitis is mild acute pancreatitis, WX-671 and WX-UK1 have been used to treat tumor metastasis and non-tumor diseases such as acute pancreatitis, gastritis, irritable bowel syndrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K31/4965A61P1/18
CPCA61K38/08A61K31/4965A61P1/18A61K2300/00
Inventor 张时群汤宇晴孟鹤林华燕
Owner LINK HEALTH GRP