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Application of thymosin beta4 in preparation of medicine for treating pulmonary fibrosis complicated with lung cancer disease

A technology for pulmonary fibrosis and thymosin, which can be used in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., and can solve problems such as lung cancer that has not yet been seen

Active Publication Date: 2021-08-27
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the relationship between Tβ4 and pulmonary fibrosis combined with lung cancer

Method used

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  • Application of thymosin beta4 in preparation of medicine for treating pulmonary fibrosis complicated with lung cancer disease
  • Application of thymosin beta4 in preparation of medicine for treating pulmonary fibrosis complicated with lung cancer disease
  • Application of thymosin beta4 in preparation of medicine for treating pulmonary fibrosis complicated with lung cancer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Example 1. Early anti-inflammatory effect of Tβ4 on lung fibrosis combined with lung cancer mouse model

[0031] 1.1 Materials and methods

[0032] 1.1.1 Reagents

[0033] Bleomycin was purchased from Nippon Kayaku Co., Ltd.; nintedanib was purchased from Dalian Meilun Biotechnology Co., Ltd.; cyclophosphamide was from MCE; ELISA kits were from mlbio; chloral hydrate was purchased from Shanghai Beinuo Biotechnology Co., Ltd.; Formaldehyde solution was purchased from Alan (Shanghai) Chemical Technology Co., Ltd.; hematoxylin dye solution was purchased from Tianjin Junyao Trading Co., Ltd.; water-soluble eosin dye solution was purchased from Tianjin Junyao Trading Co., Ltd.

[0034] 1.1.2 Animal model establishment

[0035] C57BL / 6J mice aged 6-8 weeks and weighing between 22-24 g were selected, and the mice were grouped according to experimental requirements on day 0. Weigh and record the body weight of the mouse and fix it on the operating table. The neck is disinfect...

Embodiment 2

[0055] Example 2. Anti-lung cancer and anti-fibrosis evaluation of Tβ4

[0056] 2.1 Materials and methods

[0057] 2.1.1 Reagents

[0058] Bleomycin was purchased from Nippon Kayaku Co., Ltd.; nintedanib was purchased from Dalian Meilun Biotechnology Co., Ltd.; cyclophosphamide was from MCE; ELISA kits were from mlbio; chloral hydrate was purchased from Shanghai Beinuo Biotechnology Co., Ltd.; Formaldehyde solution was purchased from Ailean (Shanghai) Chemical Technology Co., Ltd.; hematoxylin dye solution was purchased from Tianjin Junyao Trading Co., Ltd.; water-soluble eosin dye solution was purchased from Tianjin Junyao Trading Co., Ltd.; Chloramine T: p-toluenesulfonylchloramide Sodium trihydrate, p-dimethylaminobenzaldehyde, and trans-4-hydroxy-L-proline were purchased from Beijing Bailingwei Technology Co., Ltd.; perchloric acid was purchased from Shanghai Jingchun Biochemical Technology Co., Ltd.

[0059] 2.1.2 Animal model establishment

[0060] Same as Example 1 ...

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Abstract

The invention discloses application of thymosin beta4, an active fragment thereof or a derivative thereof in preparation of tumor treatment drugs. The application and the pharmaceutical preparation disclosed by the invention not only can effectively down-regulate tumor markers and inhibit lung tumor growth, but also can remarkably reduce pulmonary fibrosis, reduce inflammatory response and improve lung functions.

Description

technical field [0001] The invention discloses the application of a protein in the preparation of medicine and belongs to the field of medicine preparation. Background technique [0002] Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the past 50 years, many countries have reported that the morbidity and mortality of lung cancer have increased significantly. The incidence and mortality of lung cancer in men rank first among all malignant tumors, and the incidence and mortality of lung cancer occupy the second place in women. The cause of lung cancer is still not fully understood. Pulmonary fibrosis is a heterogeneous chronic scarring disease, including idiopathic pulmonary fibrosis (IPF) and secondary pulmonary fibrosis (SPF) caused by connective tissue diseases, drugs, occupation and other factors. IPF is the most common type of interstitial pneumonia, the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61P11/00A61P35/00
CPCA61K38/2292A61P11/00A61P35/00
Inventor 于蕊陈薇徐俊杰
Owner ACADEMY OF MILITARY MEDICAL SCI
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