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Polymer filling bone material and preparation method thereof

A technology of polymer materials and bone materials, which is applied in the fields of medical formula, medical science, tissue regeneration, etc., can solve problems such as complicated operation, and achieve the effect of simple operation, low technical content, and increased elastic modulus

Active Publication Date: 2020-08-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From your research results, we found that the composite biomaterials formed by bone graft materials and other substances have great potential for development, but although those previous methods have overcome many shortcomings, the operation has also become complicated

Method used

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  • Polymer filling bone material and preparation method thereof
  • Polymer filling bone material and preparation method thereof
  • Polymer filling bone material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The bone material was soaked in 50% ethanol prepared with pure water for 5 h, then dried naturally, and then the PDMS polydimethylsilane A and B liquids were fully mixed at a speed of 200 rpm for 10 minutes with a ratio of 1:1. min mixing, soak the dried bone material in the PDMS polydimethylsilane prepared and mixed, after blending, put it in the temperature environment of 37 ℃ for full penetration for 30 min, and then in the environment of 68 ℃ React for 6 h, and finally bake at 120 °C for 10 min, take out the baked bone material, let it stand at room temperature for 15 min, remove the PDMS polydimethylsilane covering the surface, and soak the bone material with 50% alcohol. Experiment failed.

Embodiment 2

[0019] Soak the bone material in 20% ethanol prepared with pure water for 5 h, then let it dry naturally, then fully mix the PDMS polydimethylsilane A and B liquid at a speed of 100 rpm with a ratio of 3:1 for 5 h Min mixing, soak the dried bone material in the prepared and mixed PDMS polydimethylsilane, after blending, put it in a temperature environment of 30 ℃ to fully infiltrate and cross-link for 60 minutes, and then react in an environment of 30 ℃ 8 h, and finally baked at 120 °C for 10 min, took out the baked bone material, let it stand at room temperature for 10 min, removed the PDMS polydimethylsilane covering the surface, and soaked the bone material with 25% ethanol. The experiment was successful.

Embodiment 3

[0021] The bone material was soaked in 50% ethanol prepared with pure water for 5 h, then dried naturally, and then the PDMS polydimethylsilane A and B liquids were fully mixed at a speed of 200 rpm for 10 minutes with a ratio of 5:1. min mixing, soak the dried bone material in the PDMS polydimethylsilane prepared and mixed, after blending, put it in the temperature environment of 37 ℃ for full penetration for 30 min, and then in the environment of 68 ℃ React for 6 h, and finally bake at 120 °C for 10 min, take out the baked bone material, let it stand at room temperature for 15 min, remove the PDMS polydimethylsilane covering the surface, and soak the bone material with 50% ethanol. The experiment was successful.

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Abstract

The invention discloses a polymer filled bone material and a preparation method thereof. A polymer filled bone material with bone material gaps filled with polydimethylsilane (PDMS), thereby achievingthe goals of enhancing the elasticity modulus of the bone material and maintaining the characteristics of the bone material. Great clinical values are realized on the improvement and mass productionof bone graft materials used in bone graft surgeries. Meanwhile, the invention further discloses the polymer filling bone material obtained by adopting the polymer filling bone material and a preparation method thereof.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a polymer material-filled bone material and a preparation method thereof, which is particularly suitable for improving bone graft materials so as to prepare a polymer-filled bone graft material. Background technique [0002] Bones are an important part of the human body structure, and are also the support for various functions of the human body. The health of the bones plays a decisive role in the health of the human body. In today's life, bone defects caused by accidents and personal diseases are very common in clinical practice, especially the treatment of large bone defects is quite complicated. At present, the best treatment method is bone grafting, so the selection of bone grafting materials and usage is even more important. [0003] Xenografts are a large category of bone graft materials. Xenograft bone graft materials are abundant and can be used for bone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/36A61L27/50
CPCA61L27/3608A61L27/3687A61L27/34A61L27/50A61L2400/18A61L2420/02A61L2430/02C08L83/04
Inventor 王婷帅哲玮尤柏儒
Owner SOUTHEAST UNIV
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