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Application of rhizoma corydalis pain-relieving dropping pills to treatment of knee osteoarthritis

A technology of Yuanhu Zhitong Dropping Pills and knee osteoarthritis, applied in the field of medicine, can solve the problems of severe gastrointestinal adverse reactions of diclofenac sodium, and achieve the advantages of promoting chondrocyte proliferation, good clinical treatment effect, and reducing gastrointestinal irritation. Effect

Inactive Publication Date: 2020-08-11
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the treatment of knee osteoarthritis is mainly based on surgical puncture combined with drugs, and the combination of Chinese and Western medicine. [J]. Journal of Mathematics and Medicine, 2019,32(04):100-101.) disclosed that knee joint puncture combined with Yuanhu Zhitong Dropping Pills can relieve joint pain; literature (Wang Ruiliang. Yuanhu Zhitong Dropping Pills in the treatment of acute gouty 55 cases of arthritis[J]. China Science and Technology of Traditional Chinese Medicine, 2015,022(006):716.) disclosed that Yuanhu Zhitong Dropping Pills combined with diclofenac sodium can significantly improve the treatment efficiency of acute gouty arthritis, but diclofenac sodium gastric Serious intestinal adverse reactions

Method used

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  • Application of rhizoma corydalis pain-relieving dropping pills to treatment of knee osteoarthritis
  • Application of rhizoma corydalis pain-relieving dropping pills to treatment of knee osteoarthritis
  • Application of rhizoma corydalis pain-relieving dropping pills to treatment of knee osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Animal experiment

[0019] 1. Materials and methods

[0020] 1.1 Experimental animals and grouping

[0021] 40 SPF female rats, weighing 200±20g. After adaptive feeding for 1 week, they were randomly divided into blank group, model group, Yuanhu Zhitong dropping pill group, diclofenac sodium sustained-release capsule combined with Yuanhu Zhitong dropping pill group (combined medication group), 10 rats in each group.

[0022] 1.2 Reagents and instruments

[0023] Yuanhu Zhitong Dropping Pills (Gansu Longshen Rongfa Pharmaceutical Co., Ltd.), Diclofenac Sodium Sustained-release Capsules (China Pharmaceutical University Pharmaceutical Co., Ltd.), Monoiodoacetate (MIA, Sigma, USA), IL-1α, ELISA kit of TGF-β (Beijing Oubei Biotechnology Co., Ltd.), full-wavelength scanning microplate reader (Thermo Company of the United States), low-temperature high-speed centrifuge (Beckman Company of the United States).

[0024] 1.3 Modeling method and administration metho...

Embodiment 2

[0037] Embodiment 2 clinical trials

[0038] In this example, 60 patients with knee osteoarthritis were subjected to a clinical trial.

[0039] 1. Clinical trials

[0040] 1.1 General Information

[0041] The present invention includes 60 patients with knee osteoarthritis, and is randomly assigned to group A (n=30) and group B (n=30). There was no significant difference in staging, blood routine before treatment, and blood biochemical indexes (P>0.05), which were comparable.

[0042] 1.2 Diagnostic criteria

[0043] Case selection was performed according to the diagnostic criteria of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis" issued by the Orthopedic Branch of the Chinese Medical Association in 2007:

[0044] (1) Recurrent knee joint pain in the past 1 month;

[0045] (2) X-ray film (standing or weight-bearing position) shows joint space narrowing, subchondral bone sclerosis and (or) cystic degeneration, and osteophyte formation at the joint margin...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to new application of rhizoma corydalis pain-relieving dropping pills. The inventor accidentally finds that: the rhizoma corydalis pain-relieving dropping pills can inhibit inflammatory factors by being singly used, have the effects of inhibiting cartilage degradation, promoting cartilage cell proliferation, promoting proteoglycan synthesis and the like, and has the effects superior to those of single use of diclofenac sodium sustained-release capsule and the combined use of the diclofenac sodium sustained-release capsule and the rhizoma corydalis pain-relieving dropping pills; and the inventor finds that the rhizoma corydalis pain-relieving dropping pills can obviously relieve arthralgia and ankylosis andpromote the recovery of joint activity when being independently used at the clinical level, and have good clinical treatment effect on KOA, and have obvious effect superior to that of diclofenac sodium. Compared with the diclofenac sodium, the rhizoma corydalis pain-relieving dropping pills can obviously reduce adverse reactions such as gastrointestinal tract irritation and the like when being singly used, and are high in safety after being taken for a long time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Yuanhuzhitong dripping pill for treating knee osteoarthritis. Background technique [0002] Yuanhu Zhitong Dropping Pills are composed of vinegar-made Corydalis Corydalis and Angelica dahurica. The king drug Corydalis Corydalis is the dry tuber of Corydalis yanhusuoW.T.Wang, a plant of the poppy family. The ministerial drug Angelica dahurica is Umbelliferae Angelica dahurica (Fisch.exHoffm.) Benth.etHook.f. or Hangbaizhi Angelica dahurica (Fisch.exHoffm.) Benth.etHook.f.var.formosana (Boiss.) Shan et Yuan The dried root of the root can disperse wind and cold, relieve dampness and numbness, and promote qi and blood to remove headache and body pain. The two medicines must work together, and have the effects of regulating qi, promoting blood circulation and relieving pain, and are used to treat stomach pain, headache, rib pain and dysmenorrhea caused...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K9/20A61P19/02A61P19/08A61P29/00A61K36/232
CPCA61K36/66A61K36/232A61K9/20A61P19/02A61P19/08A61P29/00A61K2300/00
Inventor 康海军邓月婷张政贾继禧
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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