45results about How to "Inhibit inflammatory factors" patented technology

The invention discloses an anti-inflammation and allergy-relieving repair composition and a preparation method and an application thereof. The composition consists of a cactus extract, an oat bran extract, a sophorae flavescentis extract, an ophiopogon japonicus root extract, a peony root extract, a scutellaria baicalensis root extract, butanediol, pentanediol and water. The preparation method comprises the following steps: 1) preparing a sophorae flavescentis extract solution; 2) carrying out super-high pressure homogenization of the cactus extract, the oat bran extract, the ophiopogon japonicus root extract, the peony root extract, the scutellaria baicalensis root extract, butanediol and pentanediol to obtain a plant extract mixed solution; and 3) carrying out mixing, super-high pressurehomogenization and filtration of the plant extract mixed solution and the sophorae flavescentis extract solution. The anti-inflammation and allergy-relieving repair composition has anti-inflammatory,anti-allergic and analgesic effects, can enhance skin barrier function, enhances the skin self-protection ability, effectively repairs inflammatory skin, especially skins suffered from hormone-dependent dermatitis and cannot produce drug resistance, dependence and side effects after being used for a long time.

The invention discloses a composition containing inonotus obliquus extract and application of composition, and aims to provide a composition which can form a layer of air breathable film on the surface of skin, effectively reducing the pollutant adhering, enhancing the natural barrier function of skin, effectively resisting irritation, allergy and other problems of outside pollutants to skin; the composition is mainly prepared from, by weight, 10-25 parts of inonotus obliquus extract, 8-20 parts of moringa pterygosperma seed extract, 5-15 parts of Bordeaux leaf extract, 3-10 parts of undaria pinnatifida extract. The composition belongs to the field of cosmetics.

The invention relates to the technical field of biomedical engineering, and provides a composition and a method related to soluble dimeric immune fusion protein. The dimeric immune fusion protein comprises a first dimerized polypeptide chain and a second dimerized polypeptide chain. The general structural formula of the first polypeptide chain is Z1-Z2, and the general structural formula of the second polypeptide chain is Y1-Y2. Z1 is (i) an extracellular domain of a first pattern recognition receptor or a functional variant or fragment thereof, or (ii) a functional variant or fragment thereofof a first co-receptor; and Z2 is a dimerized domain or a functional variant or fragment thereof. Y1 is (i) an extracellular domain of a second pattern recognition receptor or a functional variant orfragment thereof, or (ii) a second co-receptor or a functional variant or fragment thereof; and Y2 is a dimerized domain or a functional variant or fragment thereof. The dimeric protein provided by the invention can be used for blocking pathogen invasion and limiting generation and expansion of inflammatory mediators, and can be used for preparing products for preventing or treating inflammatorymediator-related diseases.

The invention belongs to the field of fermented milk products, and discloses lactobacillus gasseri and application thereof to preparation of fermented milk. A strain is the lactobacillus gasseri LGZ 1029 which is preserved in the Guangdong Microbial Culture Collection Center, short for GDMCC on April 16, 2019, and the strain preservation number is GDMCC No:60641. The probiotic lactobacillus gasseri LGZ 1029 is used as a fermentation agent, and compounded with a traditional fermented milk fermentation stain to conduct fermented milk liquid fermentation, and the lactobacillus gasseri fermented milk is prepared. A process is simple, the fermentation time is greatly shortened, the prepared fermented milk is moderate in acidity and high in viable count, no whey is separated out, better rheological properties and water-retaining capability are achieved, the taste is stick slip and delicate, aroma components are strong, and the viable count is still 10<7> CFU / mL or above after storage at 4 DEG C for 28 d.

The invention discloses a mesenchymal stem cell exosome as well as a preparation method and an application thereof, and belongs to the technical field of biomedicine. According to the invention, bonemarrow mesenchymal stem cells, adipose mesenchymal stem cells and skin mesenchymal stem cells are separated and cultured in vitro, exosomes in a cell culture supernatant are extracted by an ultracentrifugation method, and the exosomes are administrated in an articular cavity administration mode. The three exosomes derived from mesenchymal stem cells can significantly relieve related indications ofa rat with senile knee joint wear, such as improving Mankin score of a senile knee joint wear model mouse, inhibiting inflammatory factors and activating an RANK system.

The invention discloses a composition containing corn kernel extract and application of the composition containing the corn kernel extract, belongs to the technical field of cosmetics and aims to provide a composition which is capable of effectively reducing pollutant attachment, improving a natural barrier function and anti-irritation ability of the skin, removing free radicals and enhancing an antioxidant defense system while supplementing moisture and energy to the skin and effectively resisting skin allergy, aging and other problems caused by pollutants outside. The composition is mainly prepared from, by weight, 8-30 parts of corn kernel extract, 5-25 parts of moringa pterygosperma seed extract, 5-15 parts of bonamite extract, 5-10 parts of Chondrus crispus extract and 5-15 parts of Boldo leaf extract. The invention further relates to the application of the composition as an additive of anti-pollution skin care products.

The invention discloses a mild skin brightening body lotion, which comprises bacopa monniera extract, eugenol, hibiscus flower extract, jojoba seed oil, squalane, propylene glycol, glycerin, glyceryl stearate, stearyl alcohol Polyether‑21, hydrogenated olive oil and other ingredients. The mild plant active ingredients are non-irritating to the skin, and endow the product with significant anti-oxidation and antibacterial effects; the body milk of the present invention can replenish moisture to the skin, balance the skin tone, and brighten the skin color, making the skin fairer and more elastic; It can inhibit inflammatory factors and has a certain healing effect on inflamed skin.

The invention relates to the technical field of cosmetics, in particular to a composition and application thereof in preparation of cosmetics with an anti-aging function. The preparation method comprises the steps that honeysuckle extracts, camellia extracts and saussurea involucrate extracts are compounded, and the obtained composition is mixed with the components such as glycerol so that formedessence can remove free radicals and promote proliferation of fibroblasts, and the anti-aging function is achieved. Experiments show that the free radical removal rate of the essence can reach 54.84-56.01%, and the proliferation rate of the fibroblasts is increased to 14.67-24.97%.

The invention discloses application of a hydrogen molecule solid carrier in preparation of medicine for preventing and treating obesity related metabolic inflammation. According to the hydrogen molecule solid carrier, molecular hydrogen achieves a physiological effect, the carrier does not achieve the physiological effect, the reducing effect of hydrogen can be fully achieved, and prevention and treatment of obesity related metabolic inflammation are achieved from multiple levels. The application includes the steps of inhibiting increase of serum inflammatory factors in the generating process of obesity related metabolic inflammation, inhibiting increase of adipose tissue inflammatory factors, relieving adipose tissue dyslipidemia, inhibiting generation of oxidative damage in adipose tissue and inhibiting activation of inflammasome in the adipose tissue. The result shows that the hydrogen molecule solid carrier is fairly effective medicine for preventing and treating obesity related metabolic inflammation.

The invention discloses a cosmetic composition capable of relieving immediately and application thereof, which belong to the technical field of cosmetics. According to the cosmetic composition capableof relieving immediately, specific plant extracts are added to match functional components such as sodium hyaluronate with remarkable whitening and moisturizing effects, inflammatory factors such ashistamine can be inhibited and the expression intensity of TRPV1 can be reduced when the cosmetic composition is used, meanwhile, the skin barrier is effectively repaired, the damaged skin is relieved, and the skin is recovered and the health state is kept for a long time. The composition is free of additional chemical addition reagents, free of irritation to human skin and high in stability, andhas the characteristics of safety, mildness, storage resistance and high efficiency. The invention further discloses a cosmetic containing the cosmetic composition capable of relieving immediately.

The invention discloses an oil-controlling and moisturizing composition comprising: a moisturizer, an anti-inflammation repairing agent and an oil-controlling component. The moisturizer includes one or more of Belamcanda chinensis tectorigenin, glucan, chitosan, betaine, and glycerol; the oil-controlling component includes one or more of watercress extract, a methyl methacrylate crosslinked polymer, boron mononitride, Chinese wax gourd seed extract, and aloe extract. The composition can regulate water-oil balance, improve micro-circulation and lock moisture in skin, has excellent oil-controlling and moisturizing effect and has a refreshing feel on skin. When being applied to cosmetic, the composition makes a cosmetic have significant oil-controlling and moisturizing effect and enables skinto be healthier.

The invention relates to a botanical drug, and discloses an application of schisanlactone E extracted from kadsura heteroclita in preparation of a drug for resisting rheumatoid arthritis. The schisanlactone E extracted from the kadsura heteroclita can effectively inhibit the proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS), effectively inhibit the generation of lipopolysaccharide-induced inflammatory factors TNF-alpha, IL-1[beta] and IL-6 of the RAFLS and increase the expression level of IL-10, and has a relatively good anti-inflammatory effect. The occurrence rate ofAIA-induced rat arthritis can be effectively inhibited, the swelling degree of the rat toes is reduced, and the changes of pathology and radiology images of the rat toes are improved. The invention further discloses a drug with the schisanlactone E extracted from the kadsura heteroclita as an active ingredient, and the drug can be prepared into various dosage forms such as tablets, capsules or injections and is used for inhibiting the pathological changes caused by the rheumatoid arthritis and preventing bone joints from being damaged.

The invention relates to a plant composition with a function of improving an infant skin barrier and lotion of the plant composition. The plant composition is composed of the following functional raw materials of, by weight, 1-5 parts of bletilla striata, 1-3 parts of willow twig, 1-3 parts of white paeony root, 1-2 parts of oat bran and 50-500 parts of olive oil. According to the plant composition with the function of improving the infant skin barrier and the lotion of the plant composition, toxicological safety testing is conducted on the used raw materials, strict selection is conducted, using safety of the skin care product is ensured, pure natural skin care grease is adopted based on the infant skin characteristics, the skin care product is particularly suitable for infant immature skin, are safe and have no irritation to the skin through experimental verification, the effects that the skin barrier is improved, the damaged skin is repaired auxiliarily, and meanwhile the skin state can further be improved, for example, the skin elasticity and the moisture content are increased are achieved; and the component raw materials are easy to obtain, the preparation method is simple, convenient, green and safe, and the plant composition with the function of improving the infant skin barrier and the lotion of the plant composition are easy to be accepted by the crowd and have a good application prospect and a market prospect.

The invention belongs to the technical field of biological medicines, and particularly relates to an inactivated probiotic traditional Chinese medicine composition for inhibiting helicobacter pylori as well as a preparation method and application of the inactivated probiotic traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following medicinal materials in parts by weight: 18-22 parts of clove, 15-17 parts of astragalus membranaceus, 12-16 parts of dandelion, 7-11 parts of liquorice, 6-10 parts of medlar, 3-5 parts of pokeberry root, 5-9 parts of sea-buckthorn, 6-10 parts of fructus amomi and 8-12 parts of Chinese yam. The inactivated probiotics are lactobacillus plantarum ATCC 8014, lactobacillus salivarius ATCC 11741, lactobacillus acidophilus KCTC 3150 and lactobacillus reuteri DSMZ 20053. The traditional Chinese medicines are fermented for multiple times by the probiotics to improve the drug effect, the traditional Chinese medicines have the effects of inhibiting inflammatory factors and repairing gastric mucosa, and the probiotics are inactivated to remodel the micro-ecological environment in the stomach and the oral cavity to inhibit the growth of helicobacter pylori; and the eradication rate can be effectively improved through adjuvant therapy of helicobacter pylori.

The present invention relates to an application of polydatin in preparation of a drug for treating and preventing intrauterine adhesions. The polydatin is an extract obtained by alcohol extraction from dried rhizomes and roots of reynoutria japonica belonging to polygonaceae plants, and various dosage forms of the drug for treating and preventing the intrauterine adhesion at least contain the polydatin. The polydatin is used as an active ingredient, has good anti-inflammatory and anti-fibrotic effects, is remarkable in effects, clear in mechanism of action and clear in target, and meets requirements for development of pharmaceutical preparations.

The invention discloses an externally-applied traditional Chinese medicine composition with effects on inhibiting acnes and preventing pocks, which is prepared from the following raw medicines in parts by weight: 40-60 parts of red sage root, 15-30 parts of clove, 10-30 parts of astragalus root, 5-20 parts of licorice, 5-15 parts of pyracantha and 5-10 parts of marshmallow. Experiments prove that the composition disclosed by the invention can be used together with commercially available cosmetics with an acnegenic effect to inhibit the acnegenic effect of the cosmetics, and the composition has good anti-bacterial and anti-grease effects and can damage the growing environment of bacteria to completely sterilize and inhibit the bacteria, thereby playing a role in treating acnes. The composition also has a certain optimized effect on the fiber structure of the skin so as to achieve a certain smoothing effect on the pocks, and also has a fading effect on other scars induced by skin injuries. The composition has a good effect on inhibiting inflammatory factors. The composition has the advantages that the raw materials are easy to acquire, the preparation method is simple and convenient, the composition is environment-friendly and safe and is easy to be accepted by consumers, and thus the composition has good application and market prospects.

The invention discloses tobacco shreds containing a hyaluronic acid composition. The tobacco shreds are prepared from the following raw materials: a tobacco raw material, the hyaluronic acid composition, a bulking agent, an adhesive, a mildew preventive and spice. The invention further relates to a preparation method of the tobacco shreds containing the hyaluronic acid composition. According to the tobacco shreds containing the hyaluronic acid composition and the preparation method of the tobacco shreds, the hyaluronic acid composition serves as a humectant of the tobacco shreds containing thehyaluronic acid composition, the humectant of the tobacco shreds is effectively improved, the processing resistance of the tobacco shreds is improved, and the processing loss is reduced; meanwhile, the taste of the tobacco shreds is improved, irritation and dryness are reduced, and smoke is finer and smoother.

The invention relates to the field of skin care products, in particular to A61Q19 / 08. The skin care composition comprises ceramide, an alcohol humectant, an emulsifier, a carboxyl ethylene copolymer, a plant extract, a polysaccharide high-molecular compound and a solvent, and the alcohol humectant is selected from one or more of fat polyol, non-heterocyclic alcohol and oxygen-containing heterocyclic alcohol. The skin care composition has excellent barrier repairing, deep moisturizing and whitening effects. The four components in the composition play a role in coordination and have good barrier repairing and deep moisturizing effects on the skin. Besides, the four components have skin repairing and anti-allergic effects, meanwhile, also inhibit an active degree of melanocytes, thus reduce generation of melanin and achieve a whitening effect.

The invention discloses a composition for treating cervicitis. The composition comprises components in parts by weight as follows: 0.01-0.1 part of chlorhexidine, 0.05-0.5 part of borneol, 0.1-1 partof a mint extract, 10-20 parts of a plant extract, 4-12 parts of superoxide dismutase and 0.0005-0.02 part of a recombinant human epidermal growth factor; and the plant extract comprises bitter orangeflower essential oil, a chuanxiong rhizome extract and a climbing groundsel herb extract. The composition is scientific in compatibility and good in transdermal absorption and has functions of promoting circulation of qi and blood, removing erosion, promoting granulation and inhibiting inflammatory factors, can remove cervix epithelial edema, recover cervix elasticity and eliminate inflammation to regenerate mucosal tissue and repair cervical erosion wounds, has better sterilization and bacteriostatic effects and can effectively improve internal environment of vagina and quickly and effectively treat cervicitis. Besides, the composition directly acts on diseased parts, can be absorbed quickly, is highly targeted and causes little interference to internal environment of organisms, so thatthe composition is high in use safety and convenient to use.

The invention relates to a solanum photeinocarpum fruit composition for damp-heat syndrome. The composition mainly comprises the following components: a solanum photeinocarpum fruit polysaccharide extract extracted from black purple mature fruits of solanum photeinocarpum and a solanum photeinocarpum fruit glycoside extract or a solanum photeinocarpum fruit glycoside inclusion compound extracted from green immature fruits of solanum photeinocarpum, wherein the solanum photeinocarpum fruit polysaccharide extract accounts for 0.1-5% of the mass of the composition, and the solanum photeinocarpumfruit glycoside extract or the solanum photeinocarpum fruit glycoside inclusion compound accounts for 0.5-5% of the mass of the composition. The invention also relates to application of the solanum photeinocarpum fruit composition. The extraction method of the extract in the composition distinguishes the maturity of fruits, and the fruits are respectively and effectively extracted, so that more beneficial components can be obtained.

The invention discloses a health-care food for a patient with hyperlipidemia, hypertension and hypercholesterolemia, which is prepared by using the raw materials as the following effective components in parts by weight: 10-12 parts of ginkgo leaf extract, 5-7 parts of centella, 6-8 parts of salmon oil, 2-3 parts of lotus leaf, 5-8 parts of cassia seed, 5-8 parts of peach kernel, 5-8 parts of mulberry leaf, 3-5 parts of lucid ganoderma, 3-5 parts of hawthorn, 5-8 parts of foreign ginseng, 5-8 parts of salvia miltiorrhiza bunge and 8-10 parts of Chinese wolfberry fruit. The invention has simplicity and easy acquisition of raw materials, low cost and convenient taking. After the patient with hyperlipidemia, hypertension and hypercholesterolemia additional takes the health-care food, the adjuvant therapeutic effect on hyperlipidemia, hypertension and hypercholesterolemia is obvious on the premise of not changing original treatment medcaments, and the total efficiency after the patient takes for six months reaches 99.6 percent.

The invention belongs to the technical field of medicines, and particularly relates to new application of rhizoma corydalis pain-relieving dropping pills. The inventor accidentally finds that: the rhizoma corydalis pain-relieving dropping pills can inhibit inflammatory factors by being singly used, have the effects of inhibiting cartilage degradation, promoting cartilage cell proliferation, promoting proteoglycan synthesis and the like, and has the effects superior to those of single use of diclofenac sodium sustained-release capsule and the combined use of the diclofenac sodium sustained-release capsule and the rhizoma corydalis pain-relieving dropping pills; and the inventor finds that the rhizoma corydalis pain-relieving dropping pills can obviously relieve arthralgia and ankylosis andpromote the recovery of joint activity when being independently used at the clinical level, and have good clinical treatment effect on KOA, and have obvious effect superior to that of diclofenac sodium. Compared with the diclofenac sodium, the rhizoma corydalis pain-relieving dropping pills can obviously reduce adverse reactions such as gastrointestinal tract irritation and the like when being singly used, and are high in safety after being taken for a long time.

The invention discloses a sericin peptide and its application. The amino acid sequence of the sericin peptide is shown in SEQ ID NO.1. The polypeptide can be obtained by extracting the cocoon slices with water after pretreatment. The protein is obtained by hydrolysis, and can also be artificially synthesized; the obtained sericin has the effect of inhibiting inflammatory factors, so it can be used to prepare anti-inflammatory preparations.

The invention discloses novel application of carrageenan in preparing a medicament for treating serious hepatitis. The medicament can be used for inhibiting inflammatory reaction in serious hepatitis attaching process, so that attack or symptom worsening of serious hepatitis can be inhibited. Carrageenan has good curative effect in an endotoxin and D-galactosamine induced animal model; and the medicaments used in the application can be easily acquired, low in price and stable in properties, are convenient to store and transport, and have wide application prospect.

The invention relates to the technical field of biomedical engineering, and provides compositions and methods related to soluble dimer immunofusion proteins. The dimeric immunofusion protein comprises dimerized first and second polypeptide chains. The general structural formula of the first polypeptide chain is Z1-Z2, and the general structural formula of the second polypeptide chain is Y1-Y2. wherein Z1 is (i) an extracellular domain of a first pattern recognition receptor or a functional variant or fragment thereof, or (ii) a functional variant or fragment thereof of a first co-receptor; Z2 is a dimerization domain or functional variants or fragments thereof. Y1 is (i) the extracellular domain of a second pattern recognition receptor or a functional variant or fragment thereof, or (ii) a second co-receptor or a functional variant or fragment thereof, and Y2 is the dimerization domain or functional variants or fragments thereof. The dimeric protein can be used to block the invasion of pathogens, limit the production and expansion of inflammatory mediators, and can be used for the prevention of inflammatory mediator-related diseases or the preparation of therapeutic products.

The invention belongs to the technical field of cosmetics, and particularly relates to a moisturizing and anti-inflammatory composition. The composition comprises the following main effective components of peony flower extract, beet root extract and sphingomonas gum. The composition plays a role in moisturizing similar to the vitamin D, improves the transcriptional activity of a vitamin D receptor, on one hand, promotes tight connection between epidermis, on the other hand, protects calcium ion against loss, so that mitochondrial respiration is promoted to supply energy to cells, and efficient energy supply can enhance skin barriers and immune functions; in the anti-inflammatory aspect, inflammatory factors are inhibited, and the inflammatory response of skin is reduced; and through the synergistic effect of the components, excellent 24-hour moisturizing, skin barrier repairing and couperose skin reducing effects are provided for the skin.

The invention discloses a composition containing corn kernel extract and application of the composition containing the corn kernel extract, belongs to the technical field of cosmetics and aims to provide a composition which is capable of effectively reducing pollutant attachment, improving a natural barrier function and anti-irritation ability of the skin, removing free radicals and enhancing an antioxidant defense system while supplementing moisture and energy to the skin and effectively resisting skin allergy, aging and other problems caused by pollutants outside. The composition is mainly prepared from, by weight, 8-30 parts of corn kernel extract, 5-25 parts of moringa pterygosperma seed extract, 5-15 parts of bonamite extract, 5-10 parts of Chondrus crispus extract and 5-15 parts of Boldo leaf extract. The invention further relates to the application of the composition as an additive of anti-pollution skin care products.

The invention discloses an anti-inflammatory sericin peptide and its application. The amino acid sequence of the sericin peptide is shown in SEQ ID NO.1. The modified protein peptide can be obtained by pretreating cocoon slices and then extracting them with water. Sericin is obtained by hydrolysis; it can also be artificially synthesized; the obtained sericin has the effect of inhibiting inflammatory factors, so it can be used to prepare anti-inflammatory preparations.

The invention relates to a care agent for improving the infant skin barrier efficacy and a preparation process thereof. A plant composition is added in the care agent; meanwhile, the care agent consists of a phase A, a phase B and a phase C. The ingredients and the proportion of the phase A, the phase B and the phase C are optimized; and meanwhile, a preparation method of the care agent is provided. Used raw materials pass toxicological and safety performance tests and are strictly selected; the use safety of a skin care product is ensured; on the basis of the characteristics of the infant skin, pure natural skin care grease is used; and a product is particularly suitable for the tender skin of infants. Through confirmation by experiments, the care agent is safe and non-irritant on the skin; the effects of improving the skin barrier, restoring the damaged skin in an auxiliary way and improving the skin state such as skin elasticity and moisture content increase are achieved; the raw materials of a formula can be easily obtained; the preparation method is simple and convenient; green effects and safety are realized; the care agent can be easily accepted by people groups; and good application prospects and market prospects are realized.