Inactivated probiotic traditional Chinese medicine composition for inhibiting helicobacter pylori as well as preparation method and application of inactivated probiotic traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to an inactivated probiotic traditional Chinese medicine composition for inhibiting helicobacter pylori as well as a preparation method and application of the inactivated probiotic traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following medicinal materials in parts by weight: 18-22 parts of clove, 15-17 parts of astragalus membranaceus, 12-16 parts of dandelion, 7-11 parts of liquorice, 6-10 parts of medlar, 3-5 parts of pokeberry root, 5-9 parts of sea-buckthorn, 6-10 parts of fructus amomi and 8-12 parts of Chinese yam. The inactivated probiotics are lactobacillus plantarum ATCC 8014, lactobacillus salivarius ATCC 11741, lactobacillus acidophilus KCTC 3150 and lactobacillus reuteri DSMZ 20053. The traditional Chinese medicines are fermented for multiple times by the probiotics to improve the drug effect, the traditional Chinese medicines have the effects of inhibiting inflammatory factors and repairing gastric mucosa, and the probiotics are inactivated to remodel the micro-ecological environment in the stomach and the oral cavity to inhibit the growth of helicobacter pylori; and the eradication rate can be effectively improved through adjuvant therapy of helicobacter pylori.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an inactivated probiotic traditional Chinese medicine composition for inhibiting Helicobacter pylori and its preparation method and application. Background technique [0002] Helicobacter pylori (Hp) is the main pathogenic factor of chronic active gastritis, peptic ulcer, gastric MALT lymphoma and gastric cancer. The common symptoms of patients with chronic gastritis and peptic ulcer are: upper abdominal fullness, discomfort or pain after eating, often accompanied by other adverse symptoms, such as belching, abdominal distension, acid reflux and loss of appetite. Some patients also have recurrent severe abdominal pain and a small amount of upper gastrointestinal bleeding. [0003] Oral Helicobacter pylori is a Gram-negative bacterium that is distributed in saliva and dental plaque and can cause bad breath, oral ulcers, and chronic pharyngitis. Helicobacter pylori in the ora...

AI Technical Summary

Problems solved by technology

However, saliva, gastric acid, bile, and various digestive enzymes will all affect the effect of live probiotics. When live probiotics reach the intestinal tract, non-bacillus species are easily inactivated; Both normal site transfer and drug resistance gene transfer will increase the risk of pathogenic bacteria

While traditional Chinese medicine is used to treat Hp infection, the preparation methods are mostly decoctions, pills, etc., the utilization rate of effective active ingredients in the raw materials is low, there are slow effects, long treatment cycle, and poor taste.

Images