The invention discloses a 24-medical-herb moxa-cone moxibustion granule. A formula of the 24-medical-herb moxa-cone moxibustion granule comprises folium artemisiae argyi, herba solani nigri, lignum santali albi, rosemary herb, juniper berries, fructus citri sarcodactylis, pine needles, radix angelicae sinensis, flos carthami, semen persicae, radix et rhizoma salviae miltiorrhizae, tender leaves ofdiospyros kaki, lavandula angustifolia, grapefruits, folium nelumbinis, lemongrass herb, rhizoma acori tatarinowii, rhizoma atractylodis, radix angelicae dahuricae, lignum aquilariae resinatum, moschus, herba saussureae involueratae, herba rhodiolae, and flos caryophylli. The 24-medical-herb moxa-cone moxibustion granule is reasonable in design; and through multiple traditional Chinese medical herbs, effective human-body conditioning can be achieved, the moxibustion granule can act on a human body through multiple passages such as channels, collaterals, acupuncture points, nerves, body liquids and an immune system, essential energy is provided for blood circulation, cell metabolism activities and immune functions, and thus effects of beauty maintaining, health maintenance, treatment and healthcare are achieved. The invention further provides a preparation method of the 24-medical-herb moxa-cone moxibustion granule. The preparation method is easy to operate, reasonable in design and short in preparation period, effectively improves mixing uniformity of the raw materials, and is safe, stable, wide in application range, and conducive to popularization.