Unlock instant, AI-driven research and patent intelligence for your innovation.

ACE inhibitory peptide p2, its application and its preparation method

A technology of inhibitory peptides and sequences, applied in the field of ACE inhibitory peptide P2, can solve the problem of waste of fish skin resources, etc., and achieve the effect of good affinity, less toxic side effects, and high specificity

Active Publication Date: 2022-02-11
FISHERIES RES INST OF FUJIAN
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Pufferfish is a collective name for fish in the family Fuguidae of the bony fish class. With the opening and development of the pufferfish processing and utilization market, a large number of pufferfish processing and utilization by-products (such as fish skin, fish head, fish viscera, etc.) are used as Waste discarded or processed into animal feed will not only bring huge pressure to the environment, but also bring negative effects to society and a great waste of fish skin resources
At present, there is no relevant report on the extraction of ACE inhibitory peptides from puffer fish

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • ACE inhibitory peptide p2, its application and its preparation method
  • ACE inhibitory peptide p2, its application and its preparation method
  • ACE inhibitory peptide p2, its application and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] In order to enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0038] The invention discloses an ACE inhibitory peptide P2, the amino acid sequence of which is: WFRDGQELR.

[0039] The preparation method of ACE inhibitory peptide P2 comprises the following steps:

[0040] S1. Take fugu fish skin, add protease for enzymolysis, the enzymolysis temperature is controlled at 50°C-60°C, the enzyme-to-bottom ratio is 2%-4%, the pH is 11-12, and the enzymolysis time is 5h-7h. Preferably, the enzymolysis temperature is 55° C., the enzyme-to-substrate ratio is 2%, the pH is 12, and the enzymolysis time is 6 hours.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ACE inhibitory peptide P2 whose amino acid sequence is: WFRDGQELR. The invention also discloses the application of the ACE inhibitory peptide P2 in auxiliary blood pressure lowering drugs or auxiliary blood pressure lowering functional foods, and the preparation method of the ACE inhibitory peptide P2. The ACE inhibitory peptide P2 obtained in the present invention is extracted from puffer fish skin, has strong binding ability with ACE enzyme and high activity, and can be effectively used in blood pressure lowering drugs or functional foods to assist blood pressure lowering, and has high specificity , The advantages of small toxic and side effects.

Description

technical field [0001] The present invention relates to the field of biotechnology, in particular to an ACE inhibitory peptide P2. The present invention also relates to the application and preparation method of the ACE inhibitory peptide P2. Background technique [0002] The regulation of blood pressure in the human body is mainly controlled by the angiotensin system (renin-angiotensin system, RAS) and kinin system (kallikrein kinin system, KKS), and angiotensin converting enzyme (Angiotensinconverting enzyme, ACE) in these two systems plays a key role. ACE is a carboxyl dipeptidase widely distributed in mammalian tissues, mainly in vascular epithelial cells in the form of membrane-bound extracellular enzymes. In the RAS system, ACE can convert angiotensin Ⅰ (Angiotensin Ⅰ, Ang Ⅰ), which has no physiological activity, into angiotensin Ⅱ (Angiotensin Ⅱ, Ang Ⅱ), which has pressor activity. In the KKS system, ACE can degrade bradykinin into inactive fragments, resulting in v...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06C12P21/06C07K1/34A23L33/18A61K38/08A61P9/12
CPCC07K7/06C12P21/06A23L33/18A61P9/12A23V2002/00A61K38/00A23V2200/326A23V2250/55
Inventor 蔡水淋刘智禹苏永昌潘南陈晓婷廖登远
Owner FISHERIES RES INST OF FUJIAN