Preparation method of fatty acid-based VC lipidosome
A fatty acid-based, fatty acid-based technology is applied in liposome delivery, skin care preparations, medical preparations of non-active ingredients, etc. It can solve the problems of low encapsulation efficiency and damage to the stability of vitamin C, so as to promote absorption, The effect of widening the formation range
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Embodiment 1
[0048] Embodiment 1 uses the VC liposome prepared by palmitic acid-CLA-SDS
[0049] step one)
[0050] At 60°C, mix 0.1g palmitic acid and 1.3g 95% industrial CLA (CLA average molecular weight 278.73), then add the mixed CLA-palmitic acid to 250mL SDS aqueous solution (the mass concentration of SDS aqueous solution is 0.056%, containing SDS0.14g), simply mixed to obtain a mixture system. The pH of the mixture system was adjusted to pH 3.5 with dilute hydrochloric acid, and a suspension was obtained after homogenization.
[0051] Step (2)
[0052] Add 250mL of 2mg / mL VC aqueous solution dropwise to the above suspension while stirring at 25°C and 150rpm, and the VC aqueous solution will be added dropwise within 30min; shake the mixed solution after adding VC dropwise at 50rpm and 25°C Shake for 30min.
[0053] In the obtained fatty acid-based VC liposome solution, the concentration of fatty acid was 10 mmol / L, and the concentration of VC was 1 mg / mL. The encapsulation effic...
Embodiment 2
[0073] Embodiment 2 uses the VC liposome prepared by palmitic acid-CLA-SDS
[0074] step one)
[0075] At 60°C, 1g of palmitic acid and 13g of 95% industrial CLA (CLA average molecular weight 278.73) were mixed evenly, and then 250mL of SDS aqueous solution (the mass concentration of SDS aqueous solution was 0.56%, containing 1.4g of SDS) was added to the mixed CLA- In palmitic acid, simply mix to obtain a mixture system. Then, adjust the pH of the mixture system to pH 3.5 with dilute hydrochloric acid, and obtain a suspension after homogenization.
[0076] Step (2)
[0077] 250 mL of 10 mg / mL VC aqueous solution was added dropwise to the above suspension while stirring at 25°C and 150 rpm, and the addition was completed within 30 minutes. The mixed solution containing VC was shaken at 30 rpm and 25°C for 90 min.
[0078] In the obtained fatty acid-based VC liposome system, the concentration of fatty acid was 100 mmol / L, the concentration of VC was 5 mg / mL, and the encapsu...
Embodiment 3
[0080] Embodiment 3 uses the VC liposome prepared by stearic acid-CLA-SDS
[0081] step one)
[0082] Mix 1g of stearic acid and 13g of 95% industrial CLA evenly at 60°C, then add 250mL of SDS aqueous solution (the mass concentration of SDS aqueous solution is 0.56%, containing 1.4g of SDS) into the mixed CLA-stearic acid, simply Mix well to obtain a mixture system. Then, the pH of the mixture system was adjusted to pH 3.8 with dilute hydrochloric acid, and a suspension was obtained after homogenization.
[0083] Step (2)
[0084]250 mL of 10 mg / mL VC aqueous solution was added dropwise to the above suspension while stirring at 25°C and 150 rpm, and the addition was completed within 30 minutes. The mixed solution was shaken at 20 rpm for 50 min at 20°C.
[0085] In the obtained fatty acid-based VC liposome system, the concentration of fatty acid is 100mmol / L, the concentration of VC is 5mg / mL, and the encapsulation efficiency of VC is 66.5%.
[0086] Compared with Example...
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