Semiconductor sequencing device

Abstract

The invention discloses a semiconductor sequencing device, and belongs to the technical field of gene sequencing. The semiconductor sequencing device comprises a confluence block which is provided with a first liquid inlet and a first liquid outlet, a chip assembly which comprises a chip and a pressing block arranged on the chip in a pressing mode and provided with a liquid inlet channel and a liquid outlet channel, and a driving mechanism having the output end connected with the confluence block and used for driving the confluence block to be close to the chip assembly until the pressing block is pressed for enabling the first liquid outlet and the first liquid inlet of the confluence block to communicate with the liquid inlet channel and the liquid outlet channel of the pressing block, wherein a first sealing element is arranged between the first liquid inlet and the liquid outlet channel, and a first sealing element is arranged between the first liquid outlet and the liquid inlet channel. Good sealing between the confluence block and the pressing block is achieved by arranging the first sealing elements.

Description

technical field [0001] The invention relates to the technical field of gene sequencing, in particular to a semiconductor sequencing device. Background technique [0002] With the development of gene sequencing technology, the use of semiconductor technology to complete sequencing has become a new research direction. Different from the traditional optical principle for sequencing, the DNA chain is fixed in the micropore of the semiconductor chip. With the incorporation of the base, under the action of the polymerase, the sequencing primer is extended and hydrogen ions are released. The detection of ions realizes the real-time interpretation of bases on the sequence to be tested, making the sequencing process simpler, faster and less expensive. [0003] The existing semiconductor sequencing process still requires manual loading of samples to the chip on the sequencing platform. Not only is the sequencing efficiency low and the accuracy of sample loading is poor, but the seali...

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Problems solved by technology

[0003] The existing semiconductor sequencing process still requires manual loading of samples to the chip on the sequencing platform. Not only is the sequencing efficiency low and the accuracy of sample loading is poor, but the sealing of the liquid inlet and outlet of the chip is also poor during testing, resulting in reagents not being able to Effectively flow into the micropores of the chip to complete the test, the cleaning solution cannot fully clean the chip or the waste liquid cannot be discharged from the chip in time, and then the mutual doping between the liquids occurs, affecting the accuracy of the final test result

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