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Method for treating butanol crystallization mother liquor of lincomycin hydrochloride

A technology of lincomycin hydrochloride and treatment method, which is applied in the field of pharmacy, can solve problems such as difficulties, inability to guarantee product quality, low recovery rate of lincomycin hydrochloride, etc., and achieve the effect of simple recovery

Pending Publication Date: 2020-08-28
TOPFOND PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the existence of the above-mentioned proteinaceous substances in the lincomycin hydrochloride butanol crystallization mother liquor, no matter which method is adopted to process the lincomycin hydrochloride butanol crystallization mother liquor in the prior art, it is relatively difficult, and these proteinaceous substances are recovered and processed in the mother liquor. All cause very big impact in the process, make the rate of recovery of lincomycin hydrochloride very low and can not guarantee product quality

Method used

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  • Method for treating butanol crystallization mother liquor of lincomycin hydrochloride
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  • Method for treating butanol crystallization mother liquor of lincomycin hydrochloride

Examples

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Effect test

Embodiment 1

[0023] The processing method of the butanol crystallization mother liquor of lincomycin hydrochloride, the processing method comprises:

[0024] (1) Add 200ml of saturated sodium phosphate to 10000ml of lincomycin hydrochloride butanol crystallization mother liquor, then add 5000ml of water, then adjust the pH value to 8.4 with sodium hydroxide; stir well, and let it stand for 1 hour Layered to obtain supernatant and lower turbidity, and then separated;

[0025] (2) the turbid liquid of above-mentioned separation is carried out centrifugation, obtains liquid and solid; Detect lincomycin hydrochloride in supernatant with high performance liquid chromatography, detection result is as shown in lincomycin hydrochloride content in table 1 mother liquor , the supernatant is used to recover lincomycin hydrochloride; and

[0026] (3) The solid obtained in step (2) is dried. The small test is dried in an oven at 95°C under normal pressure. In production, boiling drying can be used. Th...

Embodiment 2

[0040] The processing method of the butanol crystallization mother liquor of lincomycin hydrochloride, the processing method comprises:

[0041] (1) Add 600ml of saturated sodium phosphate to 20,000ml of lincomycin hydrochloride butanol crystallization mother liquor, then add 20,000ml of water, then adjust the pH value to 9.0 with sodium hydroxide; stir well, and let stand for 1 hour Layered to obtain supernatant and lower turbidity, and then separated;

[0042] (2) the turbid liquid of above-mentioned separation is carried out centrifugation, obtains liquid and solid; Detect lincomycin hydrochloride in the supernatant with high performance liquid chromatography, detection result is as shown in the lincomycin hydrochloride content in the mother liquor of table 4 , the supernatant is used to recover lincomycin hydrochloride; and

[0043] (3) The solid obtained in step (2) is dried. The small test is dried in an oven at 95°C under normal pressure. In production, boiling drying ...

Embodiment 3

[0057] The processing method of the butanol crystallization mother liquor of lincomycin hydrochloride, the processing method comprises:

[0058] (1) Add 800ml of saturated sodium phosphate to 20,000ml of lincomycin hydrochloride butanol crystallization mother liquor, then add 15,000ml of water, then adjust the pH value to 7.5 with sodium hydroxide; stir well, and let stand for 1 hour Layered to obtain supernatant and lower turbidity, and then separated;

[0059] (2) The turbid liquid of above-mentioned separation is carried out centrifugation, obtains liquid and solid; Detect lincomycin hydrochloride in the supernatant with high performance liquid chromatography, detection result is as shown in the content of lincomycin hydrochloride in the mother liquor of table 7 , the supernatant is used to recover lincomycin hydrochloride; and

[0060] (3) The solid obtained in step (2) is dried. The small test is dried in an oven at 95°C under normal pressure. In production, boiling dryi...

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Abstract

The invention discloses a method for treating butanol crystallization mother liquor of lincomycin hydrochloride. The method comprises the following steps: (1) adding any one of EDTA, EDTA salt or phosphate to butanol crystallization mother liquor of lincomycin hydrochloride, adding water, and adjusting the pH value to 7.0-11.0 by using an alkaline solution, performing standing and layering to obtain a supernatant and a lower turbid solution, and performing separating; (2) centrifugally separating the turbid solution to obtain a liquid and a solid, wherein the supernatant is used for recoveringthe lincomycin hydrochloride, and drying the solid, directly discarding the solid generated by EDTA and EDTA salt, and fermenting the solid generated by phosphate to produce lincomycin. According tothe invention, protein substances can be separated from the butanol crystallization mother liquor of the lincomycin hydrochloride; the content of the lincomycin hydrochloride in the treated mother liquor is not reduced, and the treated butanol crystallization mother liquor is directly concentrated and crystallized or is subjected to other treatment, so that the lincomycin hydrochloride in the mother liquor is simple to recover, and the generated dried solid can be used for lincomycin fermentation production if the dried solid is generated by using the phosphate.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a method for treating the butanol crystallization mother liquor of lincomycin hydrochloride. Background technique [0002] Lincomycin, known abroad as Lincomycin (Lincomycin), also known as lincomycin, is a lincosamine-type alkaline antibiotic produced by Streptomyces lincolnensis. Lincomycin and its semi-synthesized downstream product Clindamycin (Clindamycin) is a high-efficiency broad-spectrum antibiotic that has been widely used clinically for many years and has obvious curative effects. It has a strong effect on Gram-positive bacteria and Gram-negative bacteria, and is used for osteomyelitis, sepsis, respiratory system and soft tissue infections. This product has a strong ability to penetrate bone and is the first choice for osteomyelitis. [0003] Lincomycin hydrochloride (molecular formula: C 18 h 34 N 2 o 6 S·HCl·H 2 (0), its molecular weight is 461.02, and molecu...

Claims

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Application Information

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IPC IPC(8): C07H15/16C07H1/06
CPCC07H15/16C07H1/06
Inventor 张宏周刘俭国朱德育赖珅刘守强陈中刚张增辉李磊谢书琴王雪洁王鑫张锐鲍金庆李华孟新梅
Owner TOPFOND PHARMA CO LTD
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