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Composite optical fiber device for realizing micro-dosing and photoelectric detection and preparation method

A composite optical fiber and photoelectric detection technology, which is applied in the field of electrophysiology technology, bioengineering, and optogenetics technology, can solve problems such as single function, achieve simple preparation process, small tissue trauma, drug administration and stimulation, and electrophysiological signal recording Precise Simultaneous Effects

Inactive Publication Date: 2020-09-01
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the currently used stimulation and detection devices only have a single signal stimulation and detection function, and the functions are relatively single.

Method used

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  • Composite optical fiber device for realizing micro-dosing and photoelectric detection and preparation method
  • Composite optical fiber device for realizing micro-dosing and photoelectric detection and preparation method
  • Composite optical fiber device for realizing micro-dosing and photoelectric detection and preparation method

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specific Embodiment

[0034] A specific embodiment: S1: In this embodiment, a solid cylinder of PES of suitable size is taken, and the outer diameter is preferably less than 400 microns. Process a through hole with a diameter of 105 microns, a through hole with a diameter of 150 microns and a through hole with a diameter of 160 microns in the cylinder, and ensure that the axes of the three through holes are parallel, and are used as the outer cover of the composite optical fiber; S2: optical fiber cutting The pen cuts the appropriate length of the optical fiber with a core diameter of 105 microns and places it in the 105-micron through hole so that one end protrudes out of the outer covering about 5 microns, and the other end naturally protrudes; cut the appropriate length of the titanium wire and place it in the 150-micron through hole so that one end protrudes The outer cladding is about 5 microns, and the other end is naturally protruding; a microtube preform with a total length of 160 microns in ...

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Abstract

The invention discloses a composite optical fiber device for realizing micro-dosing and photoelectric detection and a preparation method. The preparation process is simple; and the prepared compositeoptical fiber can realize micro-dosing and photoelectric stimulation in the brain of a living body and perform synchronous recording of detection results, and transmission and recording of optical, electrical and chemical signals can be effectively realized in one optical fiber. The device comprises a composite optical fiber and a connector, wherein the composite optical fiber comprises a dosing micro-tube for realizing micro-dosing into the living body, an optical fiber core for optical signal stimulation and detection, and a conductive metal wire for electric signal stimulation and electrophysiology recording. The dosing micro-tube, the optical fiber core and the conductive metal wire which are implanted into the living body are coated by an outer coating layer, and the dosing micro-tube, the optical fiber core and the conductive metal wire which are left outside the living body are connected with an in-vitro signal source of the living body through connectors respectively.

Description

Technical field [0001] The invention relates to the fields of optogenetics technology, electrophysiology technology and bioengineering technology, in particular to a composite optical fiber device for realizing micro-administration and photoelectric detection and a preparation method. Background technique [0002] At present, in the research of brain science, biomedicine and other fields, light signals, electrical signals or chemical signals are commonly used to stimulate the brain nerves of organisms and detect related responses to obtain corresponding experimental results. Devices with signal stimulation and detection functions are used in brain science, There are broad application prospects in the research of biomedicine, optogenetics and other fields. [0003] However, most of the current stimulation and detection devices only have a single signal stimulation and detection function, and their functions are relatively single. To study the effect of a certain drug on the nerve a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0476A61B5/0478A61B5/0484A61B5/00A61M31/00
CPCA61B5/0017A61M31/00A61M2210/0693A61M2210/005
Inventor 余霞田恬张昕栾汶林宋清澄张恺
Owner BEIHANG UNIV
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