Intelligent lipid carrier with whitening and sunscreen functions, and preparation method of intelligent lipid carrier

A lipid carrier, intelligent technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of low irritation, BP-3 irritation, poor stability, etc., to solve the problem of skin irritation , simple process, strong whitening and sunscreen effects

Pending Publication Date: 2020-09-04
GUANGDONG IND TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above problems, the present invention provides a smart lipid carrier with whitening and sunscreen functions and a preparation method thereof, which can coat 377 and BP-3 at the same time, and solve the problems of poor stability of 377 and high irritation of BP-3. Advantages of good stability and low irritation properties

Method used

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  • Intelligent lipid carrier with whitening and sunscreen functions, and preparation method of intelligent lipid carrier
  • Intelligent lipid carrier with whitening and sunscreen functions, and preparation method of intelligent lipid carrier
  • Intelligent lipid carrier with whitening and sunscreen functions, and preparation method of intelligent lipid carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Such as figure 1 As shown, mix 1 part of 377, 0.5 part of polyethylene glycol and add 1 part of BP-3, 1 part of stearic acid, 1 part of palmitic acid, 1 part of lauric acid, 1 part of myristic acid, 1 part of cholesterol, 2 1 part vitamin E and 2 parts caprylic capric triglyceride are used as the oil phase and mixed uniformly at 80°C to form a mixed solution;

[0032] Use 1 part of decyl glucoside, 1 part of soybean lecithin, 0.5 part of polysorbate-60, and deionized water as the water phase, heat it to 85°C, and set aside;

[0033] Pour the oil phase into the water phase, and homogenize for 5 minutes at a homogenization rate of 15,000 rap to obtain a coating;

[0034] Stir the covering body to normal temperature to prepare the smart lipid carrier with whitening and sunscreen functions.

[0035] The physical and chemical properties of smart lipid carriers were studied, including average particle size, PDI dispersion index, zeta potential and encapsulation efficiency. ...

Embodiment 2

[0038] Mix 1.5 parts of 377, 0.5 parts of polyethylene glycol and add 1.5 parts of BP-3, 1 part of behenyl alcohol, 1 part of palmityl alcohol, 1 part of cetearyl alcohol, 1 part of myristyl alcohol, 1 part of hydrogenated castor oil , 1 part glyceryl tribehenate, 1 part glyceryl trimyristate, 1 part glyceryl monolaurate, 1 part glyceryl succinate, 2.5 parts isopropyl palmitate, 2.5 parts isopropyl myristate, 2.5 parts of liquid paraffin and 2.5 parts of isooctyl palmitate and hexyl laurate are used as the oil phase, and mixed uniformly at 60°C to form a mixed solution;

[0039] 1 part of polysorbate-80, 1 part of poloxamer 407, 1 part of poloxamer 188, and deionized water were used as the water phase, heated to 65°C, and set aside;

[0040] Pour the oil phase into the water phase, and homogenize for 1 min at a homogenization rate of 25,000 rap to obtain a coating;

[0041] Stir the covering body to normal temperature to prepare the smart lipid carrier with whitening and suns...

Embodiment 3

[0044] After mixing 1.2 parts of 377 and 0.5 parts of polyethylene glycol, add 1.2 parts of BP-3, 0.2 parts of lutein esters, 0.2 parts of palmitoyl stearyl glyceryl ester, 0.2 parts of glyceryl tristearate, and 0.2 parts of monohard Glyceryl esters, 0.2 parts of glyceryl stearate citrate, 0.3 parts of 2-octyl lauryl alcohol, 0.3 parts of grape seed oil, and 0.3 parts of olive oil were uniformly mixed at 70°C to form a mixed solution;

[0045] 1 part of polysorbate-80, 0.8 part of poloxamer 407, 1 part of poloxamer 188, and deionized water were used as the water phase, heated to 80 ° C, and set aside;

[0046] Pour the oil phase into the water phase, and homogenize for 2 minutes at a homogenization rate of 20,000 rap to obtain a coating;

[0047] Stir the encapsulation body to room temperature to study the physical and chemical properties of the smart lipid carrier. The particle size is 248.3nm, the PDI dispersion index is 0.21, the zeta potential is -22.3mV, and the encapsulati...

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Abstract

The invention discloses an intelligent lipid carrier with whitening and sunscreen functions. The intelligent lipid carrier is prepared from the following components in parts by mass: 2.5 to 3 parts ofnonionic surfactant, 1 to 10 parts of solid lipid, 1 to 10 parts of 10-20% of liquid lipid, 1-1.5 parts of phenethyl resorcinol, 1 to 1.5 parts of benzophenone and 0.5 part of nucleophilic reagent; and meanwhile, 377 and BP-3 can be coated, the problems that 377 is poor in stability and BP-3 is large in irritation are solved, and the intelligent lipid carrier has the advantages of being good in stability and low in irritation.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an intelligent lipid carrier with whitening and sunscreen functions and a preparation method thereof. Background technique [0002] Nanostructured lipid carrier (NLC) technology is based on the encapsulation technology of solid lipid nanoparticles (SLN). Compared with SLN, a liquid lipid is added, which inhibits the crystallization process of solid lipid and destroys SLN. The sequenced lipid arrangement state, the obtained crystallization is not complete, and the lattice defects are increased. The active components can be loaded between the fatty acid chains or between the lipid layers and the lattice defects, which improves the loading capacity of the active components and reduces Minimizes the displacement of active ingredients during storage. [0003] Smart Lipids, using 5 or more lipids, can not only reduce a lot of energy and time in the traditional lipid screening process, but als...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/34A61K8/35A61Q17/04A61Q19/02
CPCA61K8/14A61K8/347A61K8/35A61Q17/04A61Q19/02
Inventor 温子敏徐梦漪石磊陈顺萍杨晓蓉龚盛昭
Owner GUANGDONG IND TECHN COLLEGE
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