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Ruthenium complex taking thiosemicarbazone as ligand and application thereof

A technology of thiosemicarbazone and ruthenium complexes, which is applied in the direction of ruthenium organic compounds, platinum group organic compounds, compounds containing elements of group 8/9/10/18 of the periodic table, etc., to achieve low cost, mild reaction and easy operation simple effect

Active Publication Date: 2020-09-04
GUANGXI NORMAL UNIV
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Problems solved by technology

However, there is no report on the synthesis of ruthenium metal complexes using thiosemicarbazide as a ligand

Method used

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  • Ruthenium complex taking thiosemicarbazone as ligand and application thereof
  • Ruthenium complex taking thiosemicarbazone as ligand and application thereof
  • Ruthenium complex taking thiosemicarbazone as ligand and application thereof

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Embodiment Construction

[0051] In vitro anti-tumor activity experiments were carried out on the prepared ruthenium complexes C1 and C2, the steps are as follows:

[0052] 1. The human cervical cancer cell line Hela and the normal human liver cell line HL-7702 were selected for in vitro cytotoxicity experiments;

[0053] 2. Thiazolium blue (MTT) test. Take 5×10 4Add 180 μL of cells to 96 wells at a concentration of 1 cell / mL, and continue to culture for 18 hours; add 20 μL of ruthenium complexes of different concentrations to each well, and cisplatin as a control group; continue to culture for 48 hours, add MTT and incubate for 4 hours, then slowly remove Continue to add 100 μL dimethyl sulfoxide to dissolve all the liquid; use a microplate reader to measure the absorbance at 570nm / 630nm dual wavelength, and calculate the IC 50 value, as shown in Table 1.

[0054] The results showed that: for these two cancer cell lines, simple ligands L1, L2 and RuCl 3 The activity of cisplatin is very low, and t...

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Abstract

The invention discloses a ruthenium complex taking thiosemicarbazone as a ligand and application thereof. The ruthenium complex takes 2-acetyl-3-ethylpyrazine and thiosemicarbazide or 4-phenyl-3-thiosemicarbazide as raw materials to synthesize a Schiff base ligand; and the ligand reacts with ruthenium trichloride to obtain the ruthenium complex. Two thiosemicarbazide ruthenium metal complexes C1 and C2 are designed and synthesized, the detection shows that the complex has good antitumor activity on human cervical cancer cell lines Hela, has low toxicity on human normal hepatocytes HL-7702, caneffectively inhibit Hela cell migration, and plays an important role in the development of antitumor metal drugs. The ruthenium metal complex taking thiosemicarbazone as the ligand can be used for preparing medicines for treating cervical cancer.

Description

technical field [0001] The invention relates to a ruthenium complex, in particular to a ruthenium complex with 2-acetyl-3-ethylpyrazine thiosemicarbazone as a ligand and its application. Background technique [0002] Cervical cancer is one of the most prone cancers, which has caused great harm to women's physical and mental health. At present, the main method for the treatment of cervical cancer is chemotherapy combined with radiotherapy and physical therapy. Cisplatin is often used as a chemotherapeutic drug during chemotherapy, but many side effects of cisplatin limit its clinical application to a large extent. use. [0003] Ruthenium metal complexes are widely synthesized and used in anti-tumor research, and several ruthenium complexes have been used in clinical research. However, there is no report on the synthesis of ruthenium metal complexes using thiosemicarbazide as a ligand. Contents of the invention [0004] The object of the present invention is to provide a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61K31/555A61P35/00
CPCA61P35/00C07B2200/13C07F15/0053
Inventor 杨峰江名李文娟李山河伍君淼贾小颖楚永
Owner GUANGXI NORMAL UNIV
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