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Perforated capsules

A technology of capsules and hard capsules, applied in microcapsules, capsule transportation, packaged food, etc., can solve the problems of slowing down the dissolution rate of cross-linking trend, unstable chemical angle, unstable microorganisms, etc.

Pending Publication Date: 2020-09-04
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelatin is one of the proteins derived from animals; most commonly from the bones of animals of the genus Bovis; and can be considered chemically unstable due to its tendency to cross-link, which can slow the rate of dissolution, May be microbiologically unstable and present a risk of TSE

Method used

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  • Perforated capsules
  • Perforated capsules
  • Perforated capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: Preparation of microbeads containing menthol

[0058] Part A: Preparation of Bead Coating Layer

[0059] 1. Prepare the outer coating layer using the ingredients in Table 1. Purified water was heated to 30 °C.

[0060] 2. Add glycerin, isomalt and mix.

[0061] 3. The gelatin was then added and the solution was brought to 60°C and mixed for at least one hour until dissolved.

[0062] Part B: Preparation of fill solution and formation of capsules

[0063] 1. Vegetable oil melts at about 40-55°C.

[0064] 2. Then add menthol until dissolved.

[0065] 3. Then add the silica while mixing and homogenize for about 20 minutes while mixing at about 30°C to 45°C.

[0066] 4. The material is extruded through a double nozzle and falls into a cooling solution containing vegetable oil.

[0067] 5. Collect the capsules and drain the remaining oil.

[0068] Table 1

[0069] Material mg / capsule % weight / weight Batch weight (g) coating...

Embodiment 2

[0070] Example 2: Preparation of filled capsules comprising microbeads

[0071] Three microbeads prepared in Example 1 were added to perforated gelatin capsules. Place the beads in a size zero capsule.

[0072] Perforations were made with a DPSS laser - SAML-03-N0500 (3 Watt) manually with variable timing as the capsule was rotated on the mandrel to orientate the laser.

[0073] Holes were drilled using 0.5 mm and 1.0 mm hole diameters with 4 rows of 3 or 4 holes evenly spaced across the diameter of the capsule body and a single hole at the crown of the capsule body.

Embodiment 3

[0074] Example 3: Filling material using compressed granules (briquettes)

[0075] Compressed granules are prepared for inclusion in perforated capsules. Materials are described in Table 2.

[0076] Table 2: Materials used for compressed granules

[0077]

[0078]

[0079] a: Commercially available from Mallicrodt Corporation under the tradename Compap

[0080] b: Commercially available from Ashland Corporation under the tradename Plasdone S 630

[0081] c: Commercially available from FMC Corporation under the tradename Avicel PH101

[0082] Blending and Compression Procedures:

[0083] 1. Sieve all ingredients through a #20 mesh stainless steel sieve

[0084] 2. Blend all ingredients in a turbo mixer for 5 minutes

[0085] 3. A 1.5 g tablet mass was made at 5000 lbs of compression force using a 11 / 16 flat beveled (FFBE) tool

[0086] 4. The tablet mass is then ground into large granules using a mortar and pestle

[0087] 5. Sieve the resulting large granules...

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Abstract

The present invention relates to gelatin capsules containing microbeads. The capsule has perforations that enhance the dissolution of the capsule.

Description

technical field [0001] The present invention relates to hard capsules which are perforated and contain a pharmaceutically acceptable filler, and methods for the preparation of these hard capsules. Background technique [0002] Hard capsules have traditionally been a common dosage form for prescription and over-the-counter (OTC) medicines, and many patients prefer capsules over tablets, feeling that capsules are easier to swallow. A capsule is a hard-shelled compartment made of two halves, including a body and a cap, wherein the cap closely overlaps the body portion to enclose a quantifiable amount of the pharmaceutical ingredient therein. Encapsulated quantifiable ingredients are most often in powder, liquid, paste or similar non-solid form. Capsules have long been considered the preferred dosage form for oral delivery of active ingredients, which may be in powder, liquid or granule form of varying composition for delivery to the gastrointestinal tract of humans. The advan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16A61K9/48A61K9/50A61K31/045A61K31/167
CPCA61K9/0053A61K9/1652A61K9/4808A61K31/045A61K31/167A61K9/5057A23L27/72A61J1/00A61K9/2072A61K9/4825A61K9/4833A61K9/5015A61K9/5089
Inventor S·巴格池G·P·麦克纳利
Owner JOHNSON & JOHNSON CONSUMER COPANIES