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Cross-linked collagen sponge with sustained release of ibuprofen and metronidazole and preparation method of cross-linked collagen sponge

A technology of collagen sponge and metronidazole, which is applied in the field of oral medical materials and its preparation, can solve the problems of inability to quickly stop bleeding, sterilize and relieve pain

Active Publication Date: 2020-09-11
BEIJING HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the technical problem that the existing oral materials cannot quickly stop bleeding, sterilize and relieve pain, and provide a cross-linked collagen that can stop bleeding quickly, and has slow-release ibuprofen and metronidazole with bactericidal and pain-relieving effects Sponge and its preparation method

Method used

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  • Cross-linked collagen sponge with sustained release of ibuprofen and metronidazole and preparation method of cross-linked collagen sponge
  • Cross-linked collagen sponge with sustained release of ibuprofen and metronidazole and preparation method of cross-linked collagen sponge
  • Cross-linked collagen sponge with sustained release of ibuprofen and metronidazole and preparation method of cross-linked collagen sponge

Examples

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Effect test

Embodiment 1

[0030] A cross-linked collagen sponge for sustained release of ibuprofen and metronidazole, comprising the following raw materials: 300mm 3 Cross-linked collagen sponge, 3.9mg metronidazole and 27mg ibuprofen. Prepared by supercritical solution impregnation method containing 13μg / mm 3 Concentration of metronidazole and 90μg / mm 3 Concentrated ibuprofen cross-linked collagen sponge. The prepared collagen sponge was stuffed in the wound after extraction of impacted teeth, and the gingiva was sutured.

[0031] Specific steps are as follows:

[0032] (1) Take fresh beef tendon, remove impurities such as fascia and fat, wash and cut into pieces, degrease in a 35°C water bath for 3 hours, sterilize in a 25°C water bath, add pepsin, and the pH is 1.6, the powder-to-liquid ratio (g / ml) under the condition of 1:20, extract for 24 hours to obtain a crude collagen solution, after inactivating the enzyme, purify by high performance liquid chromatography to obtain a purified collagen sw...

Embodiment 2

[0038] A cross-linked collagen sponge for sustained release of ibuprofen and metronidazole, comprising the following raw materials: 600mm 3 Cross-linked collagen sponge, 10.8 mg metronidazole and 58.2 mg ibuprofen. Prepared by supercritical solution impregnation method containing 18μg / mm 3 Concentration of metronidazole and 97μg / mm 3 Concentrated ibuprofen cross-linked collagen sponge. The cross-linked collagen sponge was stuffed into the wound after extraction of impacted teeth, and the gingiva was sutured.

[0039] Others are with embodiment 1.

Embodiment 3

[0041] A cross-linked collagen sponge for sustained release of ibuprofen and metronidazole, including the following raw materials: 1200mm 3 Cross-linked collagen sponge, 27.6mg metronidazole and 124.8mg ibuprofen. Made by supercritical solution impregnation method containing 23μg / mm 3 Concentration of metronidazole and 104μg / mm 3 Concentrated ibuprofen cross-linked collagen sponge. The prepared collagen sponge was stuffed in the wound after extraction of impacted teeth, and the gingiva was sutured.

[0042] Others are with embodiment 1.

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Abstract

The present invention relates to a cross-linked collagen sponge with sustained release of ibuprofen and metronidazole and a preparation method of the cross-linked collagen sponge, and solves technicalproblems that existing oral cavity materials cannot stop bleeding, conducting sterilization and stopping pains quickly. The cross-linked collagen sponge contains 18-33 [mu]g / mm<3> of the metronidazole and 97-118 [mu]g / mm<3> of ibuprofen, and is in a cross-linked state; the release time of the metronidazole is 5-11 days; and the sustained release time of the ibuprofen is 5-11 days . The present invention also provides the preparation method of the cross-linked collagen sponge. The cross-linked collagen sponge can be widely used in the preparation field of oral cavity materials.

Description

technical field [0001] The invention relates to an oral medical material and a preparation method thereof, in particular to a slow-release ibuprofen and metronidazole cross-linked collagen sponge and a preparation method thereof. Background technique [0002] An impacted tooth is a tooth that can only partially erupt or not erupt at all due to obstruction by adjacent teeth, bone, or soft tissue. Due to the special position of the impacted tooth, accompanied by different degrees of obstruction by soft and hard tissues, the operation is difficult. Part of the alveolar bone needs to be removed during the operation. , Severe bleeding may occur after surgery. [0003] Collagen, as a natural active material with excellent biocompatibility and degradability, has a good hemostatic effect. Its hemostatic mechanism includes: (1) Collagen molecules have good hydrophilicity, can absorb wound surface bleeding through contact with wounds, promote the formation of blood scabs, and block ...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/00A61K47/42A61P31/04A61P29/00A61P31/02A61P7/04A61K31/192
CPCA61K9/0053A61K31/192A61K31/4164A61K47/42A61P7/04A61P29/00A61P31/02A61P31/04A61K2300/00
Inventor 叶鹏魏泰
Owner BEIJING HOSPITAL