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Composite and preparation method and use thereof

A composite material and mixed solvent technology is applied in the field of composite material preparation and restoration of dental hard tissue, which can solve the problems of secondary caries, low patient adaptability, and difficulty in matching the performance of surrounding native dental hard tissue, etc. To achieve the effect of strong adsorption

Active Publication Date: 2020-09-18
SICHUAN UNIV
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Problems solved by technology

At the same time, although different types of artificial restoration materials including resin, metal, ceramic and composite materials have been widely used clinically, these materials are easily eroded by oral bacteria and difficult to match the properties of the surrounding original tooth hard tissue, making the current To a certain extent, the treatment methods have problems such as low patient adaptability, poor long-term treatment effect and secondary dental caries.

Method used

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  • Composite and preparation method and use thereof
  • Composite and preparation method and use thereof
  • Composite and preparation method and use thereof

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Embodiment Construction

[0025] An ideal tooth hard tissue restoration material faces a key scientific problem: how to realize the effective interface interaction between the material and the original tooth hard tissue in the complex environment of the oral cavity, especially in the bacterial environment, and finally rebuild and maintain the tooth for a long time hard tissue structure.

[0026] The formation of dental hard tissue is a biomineralization process, which is regulated by the organic components in the organism. These organic components mainly include hydrophobic macromolecules and acidic macromolecules. Among them, hydrophobic macromolecules such as collagen molecules form a hydrophobic matrix through self-assembly and other methods, which serve as the basic structural framework for mineralization, while acidic macromolecules immobilized on the hydrophobic matrix attract mineral ions in the solution to gather in the organic matrix. , and finally rely on the structure, charge and stereochem...

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Abstract

The invention provides a composite and a preparation method and use thereof. The preparation method comprises the following steps: acquiring polyamino acids, wherein the polyamino acids include a hydrophilic polyamino acid and a hydrophobic polyamino acid, the hydrophilic polyamino acid includes hydrophilic chain segments, and hydrophobic polyamino acid includes hydrophobic chain segments; acquiring zein and tannic acid nanoparticles; grafting the polyamino acids to the zein and tannic acid nanoparticles; and utilizing a crosslinking agent to modify carboxyl of the polyamino acids grafted to the zein and tannic acid nanoparticles to obtain the composite. The invention can realize high absorption of facing / saliva acquired pellicle underwater, forming plaque biofilm by crosslinking and biomineralization.

Description

technical field [0001] The technical field of materials of the present invention, more specifically, relates to a composite material for repairing dental hard tissue, a preparation method and application of the composite material. Background technique [0002] Oral health is one of the important indicators to measure the physical and mental health of residents. Dental hard tissue in oral tissue is the hardest part of the human body. It is characterized by high mineralization, low organic matrix content, and lack / minimal content of differentiated Active cells, so it is difficult for mature dental hard tissue to repair itself after damage. However, damage to dental hard tissues due to mechanical wear, bacteria or acidic beverages is very common. Taking children's dental caries as an example, the fourth national oral epidemiological survey released in 2018 showed that the caries rate of deciduous teeth of 5-year-old children and permanent tooth caries of 12-year-old children w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/891A61K6/62A61K6/69
CPCA61K6/891A61K6/62A61K6/69C08L87/00
Inventor 杨佼佼李继遥侯嫒琳何利邦梁坤能
Owner SICHUAN UNIV
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