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Method for designing gene loci on high-density gene chip

A high-density gene and gene locus technology, applied in the field of designing high-density gene chips on gene loci, to achieve the effect of promoting development

Active Publication Date: 2020-09-18
深圳市早知道科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Chip detection technology has two technical limitations: 1. Genotyping detection can only be performed on known genetic loci; 2. Genotyping detection can only be performed on a limited number of genetic loci

Method used

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  • Method for designing gene loci on high-density gene chip
  • Method for designing gene loci on high-density gene chip
  • Method for designing gene loci on high-density gene chip

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Embodiment Construction

[0031] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention. In addition, it should be noted that, for the convenience of description, only some structures related to the present invention are shown in the drawings but not all structures. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0032] Reference herein to an "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present invention. The occurrences of this phr...

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Abstract

The invention provides a method for designing gene loci on a high-density gene chip, comprising the following steps of: S1: collecting gene detection data of the crowd; S2: calculating the linkage disequilibrium degree among the gene loci to obtain a linkage disequilibrium degree value R2; S3: screening gene locus relationship pairs after R2; S4: connecting all key loci by taking the gene loci which appear for many times as the key loci to construct a network; S5: scoring each network to obtain the highest-rated network; S6: scoring each gene locus in the highest rated network according to thescoring conditions; and S7: selecting the highest rated gene locus. The method for designing the gene loci on the high-density gene chip can select the proper gene loci, so that the loci can obtain gene information as much as possible.

Description

technical field [0001] The invention relates to the technical field of gene chips, in particular to a method for designing gene sites on high-density gene chips. Background technique [0002] All diseases are related to genes. A gene is a functional fragment carrying genetic information on a deoxyribonucleic acid (DNA) molecule, and is a substance for biological transmission of genetic information. Genes dominate life and are the root cause of birth, old age, sickness and death. [0003] Genetic testing is to use biological gene technology to amplify the genetic information of the subject through the peripheral venous blood or other tissue cells of the subject through specific equipment and molecular biotechnology detection methods, and to analyze the DNA molecular information in the cells of the subject. It is a method for detecting and analyzing the gene types and gene defects and their expression functions contained in it. [0004] There are about 3 billion base pairs ...

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Application Information

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IPC IPC(8): G16B20/30
CPCG16B20/30Y02A90/10
Inventor 姚笑天唐森威李鹰翔陈钢郑强
Owner 深圳市早知道科技有限公司
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