The invention discloses an air-ground integrated agricultural and forestry plant protection system device and a use method. The air-ground integrated agricultural and forestry plant protection system device comprises a ground vehicle, power supply equipment, a hydraulic pump, a liquid tank and a liquid delivery flexible pipe, wherein the power supply equipment, the hydraulic pump, the liquid tank and the liquid delivery flexible pipe are arranged on the ground vehicle. The liquid delivery flexible pipe is provided with unmanned aerial vehicles and sprayers, each sprayer is provided with an electronic obstacle detector, the electronic obstacle detectors are connected with a central controller, and the central controller is connected with the unmanned aerial vehicles and electronic signal locators. Support is provided for spraying operation through the power supply equipment, the hydraulic pump and liquid tank on the ground vehicle, and the unmanned aerial vehicles suspend the liquid delivery flexible pipe for spraying operation; the central controller receives signals from the electronic signal locators so as to control the synchronization of the unmanned aerial vehicles and the ground vehicle, and the central controller controls the unmanned aerial vehicles to automatically overcome obstacles by receiving the signals of the electronic obstacle detectors. The air-ground integrated agricultural and forestry plant protection system device and the use method have the advantages that the spraying width and the spraying height can be adjusted in real time, the spraying efficiency is improved, the unmanned aerial vehicles can automatically get over the obstacles and the operation is simple.