Manufacturing method of biosensor, biosensor and application of biosensor

A biosensor and manufacturing method technology, applied in the field of biosensors, can solve the problems of high sensitivity, unfavorable probe molecule immobilization, unsatisfactory surface modification effect of field effect tube biosensors, etc., and achieve the effect of improving sensitivity

Inactive Publication Date: 2020-09-22
INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

However, high-K materials are not conducive to coupling with silane coupling agents, and are not conducive to silanization, which makes the surface modifi

Method used

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  • Manufacturing method of biosensor, biosensor and application of biosensor
  • Manufacturing method of biosensor, biosensor and application of biosensor
  • Manufacturing method of biosensor, biosensor and application of biosensor

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Embodiment Construction

[0044] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0045] Biosensor is a high-tech biological analysis and detection technology gradually developed in recent years. It tightly connects or integrates biological or bionic signal sensing components into the sensing system, which has the advantages of specificity, sensitivity, speed, portability and easy operation. . Among them, field-effect transistor (FET) biosensors are widely used in the field of biochemical medical detection because of their high sensitivity, fast...

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Abstract

The invention discloses a manufacturing method of a biosensor, the biosensor and application of the biosensor, and relates to the technical field of biosensors. Hydroxylation process treatment is carried out on the surface of the high-K material layer, the number of hydroxyl groups on the surface of the high-K material layer is increased, then functional groups for fixing probe molecules are increased, and high-sensitivity and high-specificity detection of an object to be detected is achieved. The manufacturing method of the biosensor comprises the following steps: providing a biosensitive device with a high-K material layer, and carrying out hydroxylation treatment on the surface of the high-K material layer by utilizing a hydroxylation process. The manufacturing method of the biosensor is applied to manufacturing of the biosensor, and the biosensor is applied to detection of bioactive substances.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a method for manufacturing a biosensor, a biosensor and an application of the biosensor. Background technique [0002] Biosensors are made of biologically sensitive materials as recognition elements (including enzymes, antibodies, antigens, microorganisms, tissues, nucleic acids and other biologically active substances), appropriate physical and chemical transducers (such as oxygen electrodes, photosensitive tubes, field effect tubes, piezoelectric transistors, etc.) etc.) and an analysis tool or system composed of a signal amplification device, the sensitivity of the biosensor determines the accuracy and rapidity of the detection. Field Effect Transistor (FET for short) biosensors have attracted widespread attention because they can directly convert biological signals into electrical signals. Before using the field effect tube biosensor for detection, it is necessary to modi...

Claims

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Application Information

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IPC IPC(8): G01N27/414C09C1/40C09C1/00C09C3/04C09C3/12C09C3/08C09C3/06
CPCG01N27/4145C09C1/407C09C1/00C09C3/003C09C3/006C09C3/04C09C3/048C09C3/06C09C3/08C09C3/12
Inventor 张楠张青竹张静张兆浩魏千惠屠海令殷华湘赵鸿斌王文武
Owner INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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